Quantification of Myocardial Blood Flow in Absolute Terms Using 82Rb PET Imaging The RUBY-10 Study

被引：147

作者：

Nesterov, Sergey V. ^{[1
,2
,3
]}

Deshayes, Emmanuel ^{[4
,5
]}

Sciagra, Roberto ^{[6
]}

Settimo, Leonardo ^{[6
]}

Declerck, Jerome M. ^{[7
]}

Pan, Xiao-Bo ^{[7
]}

Yoshinaga, Keiichiro ^{[8
]}

Katoh, Chietsugu ^{[8
]}

Slomka, Piotr J. ^{[9
]}

Germano, Guido ^{[9
]}

Han, Chunlei ^{[1
,2
]}

Aalto, Ville ^{[1
,2
]}

Alessio, Adam M. ^{[10
]}

Ficaro, Edward P. ^{[11
]}

Lee, Benjamin C. ^{[12
]}

Nekolla, Stephan G. ^{[13
]}

Gwet, Kilem L. ^{[14
]}

deKemp, Robert A. ^{[15
]}

Klein, Ran ^{[15
]}

Dickson, John ^{[16
]}

Case, James A. ^{[17
]}

Bateman, Timothy ^{[17
]}

Prior, John O. ^{[4
]}

Knuuti, Juhani M. ^{[1
,2
]}

机构：

[1] Univ Turku, Turku PET Ctr, Turku 20520, Finland

[2] Turku Univ Hosp, FIN-20520 Turku, Finland

[3] RAS, IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg, Russia

[4] Univ Lausanne Hosp, Lausanne, Switzerland

[5] Reg Canc Inst Montpellier ICM Val Aurelle, Montpellier, France

[6] Univ Florence, Florence, Italy

[7] Siemens Mol Imaging, Oxford, England

[8] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan

[9] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[10] Univ Washington, Seattle, WA 98195 USA

[11] Univ Michigan Hlth Syst, Ann Arbor, MI USA

[12] INVIA Med Imaging Solut, Ann Arbor, MI USA

[13] Tech Univ Munich, Dept Nucl Med, D-80290 Munich, Germany

[14] Adv Analyt LLC, Gaithersburg, MD USA

[15] Univ Ottawa, Inst Heart, Natl Cardiac PET Ctr, Ottawa, ON, Canada

[16] UCL, London, England

[17] Cardiovasc Imaging Technol, Kansas City, MO USA

来源：

JACC-CARDIOVASCULAR IMAGING | 2014年 / 7卷 / 11期

基金：

芬兰科学院; 美国国家卫生研究院;

关键词：

CAD; imaging software; PET; reproducibility; rubidium-82; POSITRON-EMISSION-TOMOGRAPHY; GENERATOR-PRODUCED RB-82; CORONARY-ARTERY-DISEASE; PROGNOSTIC VALUE; N-13-AMMONIA PET; PERFUSION; RESERVE; STRESS; MODEL; REPRODUCIBILITY;

D O I：

10.1016/j.jcmg.2014.08.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography (Rb-82 PET) data using 10 software packages (SPs) based on 8 tracer kinetic models. BACKGROUND It is unknown how MBF and MFR values from existing SPs agree for Rb-82 PET. METHODS Rest and stress Rb-82 PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs. RESULTS The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM. CONCLUSIONS SPs using the most common kinetic model-OHI-1-TCM-provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol. (C) 2014 by the American College of Cardiology Foundation.

引用

页码：1119 / 1127

页数：9

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