Ultrasound-Triggered Regulation of Blood Glucose Levels Using Injectable Nano-Network

被引：66

作者：

Di, Jin ^{[1
,2
]}

Price, Jennifer ^{[1
,2
]}

Gu, Xiao ^{[3
]}

Jiang, Xiaoning ^{[4
]}

Jing, Yun ^{[4
]}

Gu, Zhen ^{[1
,2
,5
]}

机构：

[1] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27695 USA

[2] N Carolina State Univ, Raleigh, NC 27695 USA

[3] Yangzhou Univ, Clin Med Coll, Dept Urol, Yangzhou 225001, Jiangsu, Peoples R China

[4] N Carolina State Univ, Dept Mech Engn, Raleigh, NC 27695 USA

[5] Univ N Carolina, Eshelman Sch Pharm, Mol Pharmaceut Div, Chapel Hill, NC 27599 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2014年 / 3卷 / 06期

关键词：

HIGH-FREQUENCY ULTRASOUND; INSULIN DELIVERY; DRUG-DELIVERY; RELEASE; TISSUE; NANOPARTICLES; MICROBUBBLES; CHALLENGES; CHEMISTRY; SYSTEMS;

D O I：

10.1002/adhm.201300490

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vitro and in vivo. A single subcutaneous injection of the nano-network with intermittent FUS administration facilitates reduction of the blood glucose levels in type 1 diabetic mice for up to 10 d. © 2013 WILEY-VCH Verlag GmbH & Co.

引用

页码：811 / 816

页数：6

共 37 条

[1]

American Diabetes Association, 2010, DIABETES CARE, V33, pS11, DOI DOI 10.2337/dc10-S011

[2] Biodegradation and biocompatibility of PLA and PLGA microspheres [J].

Anderson, James M. ;

Shive, Matthew S. .

ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 :72-82

[3] Materials for Diabetes Therapeutics [J].

Bratlie, Kaitlin M. ;

York, Roger L. ;

Invernale, Michael A. ;

Langer, Robert ;

Anderson, Daniel G. .

ADVANCED HEALTHCARE MATERIALS, 2012, 1 (03) :267-284

[4] Characterization of glucose-mediated insulin release from implantable polymers [J].

Brown, LR ;

Edelman, ER ;

FischelGhodsian, F ;

Langer, R .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (12) :1341-1345

[5] PLGA-based nanoparticles: An overview of biomedical applications [J].

Danhier, Fabienne ;

Ansorena, Eduardo ;

Silva, Joana M. ;

Coco, Regis ;

Le Breton, Aude ;

Preat, Veronique .

JOURNAL OF CONTROLLED RELEASE, 2012, 161 (02) :505-522

[6] Driving delivery vehicles with ultrasound [J].

Ferrara, Katherine W. .

ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (10) :1097-1102

[7] Effect of ultrasound on the release of micro-encapsulated drugs [J].

Frinking, PJA ;

Bouakaz, A ;

de Jong, N ;

Ten Cate, FJ ;

Keating, S .

ULTRASONICS, 1998, 36 (1-5) :709-712

[8]

Fu Y, 2013, DIABETES TECHNOL THE, V15, pA79

[9] Injectable Nano-Network for Glucose-Mediated Insulin Delivery [J].

Gu, Zhen ;

Aimetti, Alex A. ;

Wang, Qun ;

Dang, Tram T. ;

Zhang, Yunlong ;

Veiseh, Omid ;

Cheng, Hao ;

Langer, Robert S. ;

Anderson, Daniel G. .

ACS NANO, 2013, 7 (05) :4194-4201

[10] The Economic Costs of Diabetes: Is It Time for a New Treatment Paradigm? [J].

Herman, William H. .

DIABETES CARE, 2013, 36 (04) :775-776

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