Ultrasound-Triggered Regulation of Blood Glucose Levels Using Injectable Nano-Network

被引：65

作者：

Di, Jin ^{[1
,2
]}

Price, Jennifer ^{[1
,2
]}

Gu, Xiao ^{[3
]}

Jiang, Xiaoning ^{[4
]}

Jing, Yun ^{[4
]}

Gu, Zhen ^{[1
,2
,5
]}

机构：

[1] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27695 USA

[2] N Carolina State Univ, Raleigh, NC 27695 USA

[3] Yangzhou Univ, Clin Med Coll, Dept Urol, Yangzhou 225001, Jiangsu, Peoples R China

[4] N Carolina State Univ, Dept Mech Engn, Raleigh, NC 27695 USA

[5] Univ N Carolina, Eshelman Sch Pharm, Mol Pharmaceut Div, Chapel Hill, NC 27599 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2014年 / 3卷 / 06期

关键词：

HIGH-FREQUENCY ULTRASOUND; INSULIN DELIVERY; DRUG-DELIVERY; RELEASE; TISSUE; NANOPARTICLES; MICROBUBBLES; CHALLENGES; CHEMISTRY; SYSTEMS;

D O I：

10.1002/adhm.201300490

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vitro and in vivo. A single subcutaneous injection of the nano-network with intermittent FUS administration facilitates reduction of the blood glucose levels in type 1 diabetic mice for up to 10 d. © 2013 WILEY-VCH Verlag GmbH & Co.

引用

页码：811 / 816

页数：6

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