Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice

被引:1
作者
Lee, Jin [1 ]
Lee, Hae-In [1 ]
Seo, Kown-Il [1 ]
Cho, Hyun Wook [2 ]
Kim, Myung-Joo [3 ]
Park, Eun-Mi [3 ]
Lee, Mi-Kyung [1 ]
机构
[1] Sunchon Natl Univ, Dept Food & Nutr, Sunchon 540950, Jeonnam, South Korea
[2] Sunchon Natl Univ, Dept Biol, Sunchon 540950, Jeonnam, South Korea
[3] Suseong Coll, Dept Hotel Cusine, Taegu 706022, South Korea
基金
新加坡国家研究基金会;
关键词
Dyslipidemia; Kidney; Liver; Polypol pathway; Ursolic acid; ADVANCED GLYCATION ENDPRODUCTS; CORONARY-HEART-DISEASE; ALDOSE REDUCTASE; OLEANOLIC ACID; RISK-FACTORS; GLUCOKINASE; METFORMIN; HYPERGLYCEMIA; CONSEQUENCES; EXPRESSION;
D O I
暂无
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ursolic acid (UA) is a pentacyclic triterpenoid compound that naturally occurs in fruits, leaves and flowers of medicinal herbs. This study investigated the dose-response efficacy of UA (0.01 and 0.05%) on glucose metabolism, the polyol pathway and dyslipidemia in streptozotocin/nicotinamide-induced diabetic mice. Supplement with both UA doses reduced fasting blood glucose and plasma triglyceride levels in non-obese type 2 diabetic mice. High-dose UA significantly lowered plasma free fatty acid, total cholesterol and VLDL-cholesterol levels compared with the diabetic control mice, while LDL-cholesterol levels were reduced with both doses. UA supplement effectively decreased hepatic glucose-6-phosphatase activity and increased glucokinase activity, the glucokinase/glucose-6-phosphatase ratio, GLUT2 mRNA levels and glycogen content compared with the diabetic control mice. UA supplement attenuated hyperglycemia-induced renal hypertrophy and histological changes. Renal aldose reductase activity was higher, whereas sorbitol dehydrogenase activity was lower in the diabetic control group than in the non-diabetic group. However, UA supplement reversed the biochemical changes in polyol pathway to normal values. These results demonstrated that low-dose UA had preventive potency for diabetic renal complications, which could be mediated by changes in hepatic glucose metabolism and the renal polyol pathway. High-dose UA was more effective anti-dyslipidemia therapy in non-obese type 2 diabetic mice.
引用
收藏
页码:683 / 691
页数:9
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