A Multi-layer Molecular Fresco of the Immune Diversity across Hematologic Malignancies

被引：3

作者：

Bedognetti, Davide ^{[1
,2
]}

机构：

[1] Sidra Med, Dept Canc Res, Doha, Qatar

[2] Univ Genoa, Dept Internal Med & Med Specialties, Genoa, Italy

来源：

CANCER CELL | 2020年 / 38卷 / 03期

关键词：

D O I：

10.1016/j.ccell.2020.08.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint blockade has limited activity in the large majority of hematologic malignancies. In this issue of Cancer Cell, Dufva et al. provide an immunologic portrait of these heterogenous diseases and identify key relationships between oncogenic states and immune response that can spur the development of more efficient immunotherapeutic approaches.

引用

页码：313 / 316

页数：5

共 10 条

[1] Evolution of Metastases in Space and Time under Immune Selection [J].

Angelova, Mihaela ;

Mlecnik, Bernhard ;

Vasaturo, Angela ;

Bindea, Gabriela ;

Fredriksen, Tessa ;

Lafontaine, Lucie ;

Buttard, Benedicte ;

Morgand, Erwan ;

Bruni, Daniela ;

Jouret-Mourin, Anne ;

Hubert, Catherine ;

Kartheuser, Alex ;

Humblet, Yves ;

Ceccarelli, Michele ;

Syed, Najeeb ;

Marincola, Francesco M. ;

Bedognetti, Davide ;

Van den Eynde, Marc ;

Galon, Jerome .

CELL, 2018, 175 (03) :751-+

[2] Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop [J].

Bedognetti, Davide ;

Ceccarelli, Michele ;

Galluzzi, Lorenzo ;

Lu, Rongze ;

Palucka, Karolina ;

Samayoa, Josue ;

Spranger, Stefani ;

Warren, Sarah ;

Wong, Kwok-Kin ;

Ziv, Elad ;

Chowell, Diego ;

Coussens, Lisa M. ;

De Carvalho, Daniel D. ;

DeNardo, David G. ;

Galon, Jerome ;

Kaufman, Howard L. ;

Kirchhoff, Tomas ;

Lotze, Michael T. ;

Luke, Jason J. ;

Minn, Andy J. ;

Politi, Katerina ;

Shultz, Leonard D. ;

Simon, Richard ;

Thorsson, Vesteinn ;

Weidhaas, Joanne B. ;

Ascierto, Maria Libera ;

Ascierto, Paolo Antonio ;

Barnes, James M. ;

Barsan, Valentin ;

Bommareddy, Praveen K. ;

Bot, Adrian ;

Church, Sarah E. ;

Ciliberto, Gennaro ;

De Maria, Andrea ;

Draganov, Dobrin ;

Ho, Winson S. ;

McGee, Heather M. ;

Monette, Anne ;

Murphy, Joseph F. ;

Nistico, Paola ;

Park, Wungki ;

Patel, Maulik ;

Quigley, Michael ;

Radvanyi, Laszlo ;

Raftopoulos, Harry ;

Rudqvist, Nils-Petter ;

Snyder, Alexandra ;

Sweis, Randy F. ;

Valpione, Sara ;

Butterfield, Lisa H. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7

[3] Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study [J].

Daver, Naval ;

Garcia-Manero, Guillermo ;

Basu, Sreyashi ;

Boddu, Prajwal C. ;

Alfayez, Mansour ;

Cortes, Jorge E. ;

Konopleva, Marina ;

Ravandi-Kashani, Farhad ;

Jabbour, Elias ;

Kadia, Tapan ;

Nogueras-Gonzalez, Graciela M. ;

Ning, Jing ;

Pemmaraju, Naveen ;

DiNardo, Courtney D. ;

Andreeff, Michael ;

Pierce, Sherry A. ;

Gordon, Tauna ;

Kornblau, Steven M. ;

Flores, Wilmer ;

Alhamal, Zainab ;

Bueso-Ramos, Carlos ;

Jorgensen, Jeffrey L. ;

Patel, Keyur P. ;

Blando, Jorge ;

Allison, James P. ;

Sharma, Padmanee ;

Kantarjian, Hagop .

CANCER DISCOVERY, 2019, 9 (03) :370-383

[4] Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma [J].

Dong, Zhong-Yi ;

Zhong, Wen-Zhao ;

Zhang, Xu-Chao ;

Su, Jian ;

Xie, Zhi ;

Liu, Si-Yang ;

Tu, Hai-Yan ;

Chen, Hua-Jun ;

Sun, Yue-Li ;

Zhou, Qing ;

Yang, Jin-Ji ;

Yang, Xue-Ning ;

Lin, Jia-Xin ;

Yan, Hong-Hong ;

Zhai, Hao-Ran ;

Yan, Li-Xu ;

Liao, Ri-Qiang ;

Wu, Si-Pei ;

Wu, Yi-Long .

CLINICAL CANCER RESEARCH, 2017, 23 (12) :3012-3024

[5] Immunogenomic Landscape of Hematological Malignancies [J].

Dufva, Olli ;

Polonen, Petri ;

Bruck, Oscar ;

Keranen, Mikko Ai ;

Klievink, Jay ;

Mehtonen, Juha ;

Huuhtanen, Jani ;

Kumar, Ashwini ;

Malani, Disha ;

Siitonen, Sanna ;

Kankainen, Matti ;

Ghimire, Bishwa ;

Lahtela, Jenni ;

Mattila, Pirkko ;

Vaha-Koskela, Markus ;

Wennerberg, Krister ;

Granberg, Kirsi ;

Leivonen, Suvi-Katri ;

Meriranta, Leo ;

Heckman, Caroline ;

Leppa, Sirpa ;

Nykter, Matti ;

Lohi, Olli ;

Heinaniemi, Merja ;

Mustjoki, Satu .

CANCER CELL, 2020, 38 (03) :380-+

[6] CRISPR treatment inserted directly into the body for first time [J].

Ledford, Heidi .

NATURE, 2020, 579 (7798) :185-185

[7] Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens [J].

Malekzadeh, Parisa ;

Yossef, Rami ;

Cafri, Gal ;

Paria, Biman C. ;

Lowery, Frank J. ;

Jafferji, Mohammad ;

Good, Meghan L. ;

Sachs, Abraham ;

Copeland, Amyr. ;

Kim, Sanghyun P. ;

Kivitz, Scott ;

Parkhurst, Maria R. ;

Robbins, Paul F. ;

Ray, Satyajit ;

Xi, Liqiang ;

Raffeld, Mark ;

Yu, Zhiya ;

Restifo, Nicholas P. ;

Somerville, Robert P. T. ;

Rosenberg, Steven A. ;

Deniger, Drew C. .

CLINICAL CANCER RESEARCH, 2020, 26 (06) :1267-1276

[8] Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response [J].

Roelands, Jessica ;

Hendrickx, Wouter ;

Zoppoli, Gabriele ;

Mall, Raghvendra ;

Saad, Mohamad ;

Halliwill, Kyle ;

Curigliano, Giuseppe ;

Rinchai, Darawan ;

Decock, Julie ;

Delogu, Lucia G. ;

Turan, Tolga ;

Samayoa, Josue ;

Chouchane, Lotfi ;

Ballestrero, Alberto ;

Wang, Ena ;

Finetti, Pascal ;

Bertucci, Francois ;

Miller, Lance D. ;

Galon, Jerome ;

Marincola, Francesco M. ;

Kuppen, Peter J. K. ;

Ceccarelli, Michele ;

Bedognetti, Davide .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)

[9]

Thorsson V, 2019, IMMUNITY, V51, P411, DOI [10.1016/j.immuni.2019.08.004, 10.1016/j.immuni.2018.03.023]

[10] Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia [J].

Vadakekolathu, Jayakumar ;

Minden, Mark D. ;

Hood, Tressa ;

Church, Sarah E. ;

Reeder, Stephen ;

Altmann, Heidi ;

Sullivan, Amy H. ;

Viboch, Elena J. ;

Patel, Tasleema ;

Ibrahimova, Narmin ;

Warren, Sarah E. ;

Arruda, Andrea ;

Liang, Yan ;

Smith, Thomas H. ;

Foulds, Gemma A. ;

Bailey, Michael D. ;

Gowen-MacDonald, James ;

Muth, John ;

Schmitz, Marc ;

Cesano, Alessandra ;

Pockley, A. Graham ;

Valk, Peter J. M. ;

Lowenberg, Bob ;

Bornhaeuser, Martin ;

Tasian, Sarah K. ;

Rettig, Michael P. ;

Davidson-Moncada, Jan K. ;

DiPersio, John F. ;

Rutella, Sergio .

SCIENCE TRANSLATIONAL MEDICINE, 2020, 12 (546)

← 1 →