Glucocorticoids for Management of Polymyalgia Rheumatica and Giant Cell Arteritis

被引：38
作者：
Matteson, Eric L. [1 ,2 ]
Buttgereit, Frank [3 ]
Dejaco, Christian [4 ,5 ]
Dasgupta, Bhaskar [6 ]
机构：
[1] Mayo Clin, Coll Med, Dept Internal Med, Div Rheumatol, Rochester, MN 55902 USA
[2] Mayo Clin, Coll Med, Dept Hlth Sci Res, Div Epidemiol, Rochester, MN 55902 USA
[3] Charite, Dept Rheumatol & Clin Immunol, D-10117 Berlin, Germany
[4] Med Univ Graz, Dept Rheumatol, A-8036 Graz, Austria
[5] Med Univ Graz, Dept Immunol, A-8036 Graz, Austria
[6] Southend Univ Hosp, Dept Rheumatol, Westcliff On Sea SS0 0RY, Essex, England
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2016年 / 42卷 / 01期
关键词：
Glucocorticoids; Polymyalgia rheumatica; Giant cell arteritis; Treatment; PLACEBO-CONTROLLED TRIAL; LARGE-VESSEL VASCULITIS; POPULATION-BASED COHORT; DOUBLE-BLIND; TEMPORAL ARTERITIS; CLASSIFICATION CRITERIA; INITIAL TREATMENT; RANDOMIZED-TRIAL; CYCLOSPORINE-A; THERAPY;
D O I：
10.1016/j.rdc.2015.08.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diagnosis of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) is based on typical clinical, histologic, and laboratory features. Ultrasonographic imaging in PMR with assessment especially of subdeltoid bursitis can aid in diagnosis and in following response to treatment. In GCA, diagnosis and disease activity are supported with ultrasonographic, MRI, or [F-18]fluorodeoxyglucose PET evaluation of large vessels. Glucocorticoids are the primary therapy for PMR and GCA. Methotrexate may be used in patients at high risk for glucocorticoid adverse effects and patients with frequent relapse or needing protracted therapy. Other therapeutic approaches including interleukin 6 antagonists are under evaluation.
引用
收藏
页码：75 / +
页数：17
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