Statin use is not associated with reduced risk of skin cancer: a meta-analysis

被引：33
作者：
Li, X. [1 ]
Wu, X. B. [1 ]
Chen, Q. [1 ]
机构：
[1] Southern Med Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China
来源：
BRITISH JOURNAL OF CANCER | 2014年 / 110卷 / 03期
关键词：
skin cancer; melanoma; non-melanoma; 3-hydroxy-3-methylglutaryl coenzyme; statin; MERKEL CELL-CARCINOMA; CORONARY EVENTS; MELANOMA RISK; MORTALITY; SIMVASTATIN; PRAVASTATIN; APOPTOSIS; PATHWAY;
D O I：
10.1038/bjc.2013.762
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: There is contradictory evidence about the association between statin and skin cancer. Methods: Literature search in PubMed and Web of Science was undertaken up to June 2013. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated. Result: A total of 21 articles with 29 studies were identified. No association was found between statin and skin cancer among neither melanoma (RR, 0.94; 95% CI, 0.85-1.04) nor non-melanoma skin cancer (RR, 1.03; 95% CI, 0.90-1.19). Conclusion: Our meta-analysis does not support a potential role of statin use in the prevention of skin cancer.
引用
收藏
页码：802 / 807
页数：6
相关论文
共 44 条
  • [1] [Anonymous], 2000, ITAL HEART J
  • [2] [Anonymous], 2013, Cancer Facts and Figures 2013
  • [3] [Anonymous], NATL GEOGR
  • [4] [Anonymous], 2017, The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
  • [5] The effects of cholesterol lowering with simvastatin on cause-specific mortality and on cancer incidence in 20,536 high-risk people: a randomised placebo-controlled trial [ISRCTN48489393]
    Armitage, Jane
    Collins, Rory
    Bowman, Louise
    Parish, Sarah
    Sleight, Peter
    Peto, Richard
    Meade, T.
    Youngman, L.
    Buxton, M.
    de Bono, D.
    George, C.
    Fuller, J.
    Keech, A.
    Mansfield, A.
    Pentecost, B.
    Simpson, D.
    Warlow, C.
    McNamara, J.
    O'Toole, L.
    Doll, R.
    Wilhelmsen, L.
    Fox, K. M.
    Hill, C.
    Sandercock, P.
    [J]. BMC MEDICINE, 2005, 3 (1)
  • [6] Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials
    Bonovas, Stefanos
    Nikolopoulos, Georgios
    Filioussi, Kalitsa
    Peponi, Evangelia
    Bagos, Pantelis
    Sitaras, Nikolaos M.
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2010, 25 (01) : 29 - 35
  • [7] Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma
    Carroll, Robert P.
    Segundo, David San
    Hollowood, Kevin
    Marafioti, Teresa
    Clark, Taane G.
    Harden, Paul N.
    Wood, Kathryn J.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (04): : 713 - 722
  • [8] Targeting tumor cell metabolism with statins
    Clendening, J. W.
    Penn, L. Z.
    [J]. ONCOGENE, 2012, 31 (48) : 4967 - 4978
  • [9] Dysregulation of the mevalonate pathway promotes transformation
    Clendening, James W.
    Pandyra, Aleks
    Boutros, Paul C.
    El Ghamrasni, Samah
    Khosravi, Fereshteh
    Trentin, Grace A.
    Martirosyan, Anna
    Hakem, Anne
    Hakem, Razqallah
    Jurisica, Igor
    Penn, Linda Z.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (34) : 15051 - 15056
  • [10] Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation
    Coimbra, Maria
    Banciu, Manuela
    Fens, Marcel H. A. M.
    de Smet, Lieselotte
    Cabaj, Magda
    Metselaar, Josbert M.
    Storm, Gert
    Schiffelers, Raymond M.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2010, 148 (03) : 303 - 310
12345