Statin use is not associated with reduced risk of skin cancer: a meta-analysis

被引：34
作者：
Li, X. [1 ]
Wu, X. B. [1 ]
Chen, Q. [1 ]
机构：
[1] Southern Med Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China
来源：
BRITISH JOURNAL OF CANCER | 2014年 / 110卷 / 03期
关键词：
skin cancer; melanoma; non-melanoma; 3-hydroxy-3-methylglutaryl coenzyme; statin; MERKEL CELL-CARCINOMA; CORONARY EVENTS; MELANOMA RISK; MORTALITY; SIMVASTATIN; PRAVASTATIN; APOPTOSIS; PATHWAY;
D O I：
10.1038/bjc.2013.762
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: There is contradictory evidence about the association between statin and skin cancer. Methods: Literature search in PubMed and Web of Science was undertaken up to June 2013. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated. Result: A total of 21 articles with 29 studies were identified. No association was found between statin and skin cancer among neither melanoma (RR, 0.94; 95% CI, 0.85-1.04) nor non-melanoma skin cancer (RR, 1.03; 95% CI, 0.90-1.19). Conclusion: Our meta-analysis does not support a potential role of statin use in the prevention of skin cancer.
引用
收藏
页码：802 / 807
页数：6
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