Outcome of Transplantation for Acute Lymphoblastic Leukemia in Children With Down Syndrome

被引：25

作者：

Hitzler, Johann K. ^{[1
]}

He, Wensheng ^{[2
]}

Doyle, John ^{[1
]}

Cairo, Mitchell ^{[3
]}

Camitta, Bruce M. ^{[4
]}

Chan, Ka Wah ^{[5
]}

Diaz Perez, Miguel A. ^{[6
]}

Fraser, Christopher ^{[7
]}

Gross, Thomas G. ^{[8
]}

Horan, John T. ^{[9
]}

Kennedy-Nasser, Alana A. ^{[10
]}

Kitko, Carrie ^{[11
]}

Kurtzberg, Joanne ^{[12
]}

Lehmann, Leslie ^{[13
]}

O'Brien, Tracey ^{[14
]}

Pulsipher, Michael A. ^{[15
]}

Smith, Franklin O. ^{[16
]}

Zhang, Mei-Jie ^{[2
]}

Eapen, Mary ^{[2
]}

Carpenter, Paul A. ^{[17
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[2] Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[3] New York Med Coll, Valhalla, NY 10595 USA

[4] Med Coll Wisconsin, Midwest Ctr Canc & Blood Disorders, Milwaukee, WI 53226 USA

[5] Texas Transplant Inst, San Antonio, TX USA

[6] Hosp Nino Jesus, Madrid, Spain

[7] Royal Childrens Hosp, Herston, Qld, Australia

[8] Nationwide Childrens Hosp, Columbus, OH USA

[9] Childrens Healthcare Atlanta Egleston, Atlanta, GA USA

[10] Texas Childrens Hosp, Baylor Coll Med, Houston, TX 77030 USA

[11] Univ Michigan, Ann Arbor, MI 48109 USA

[12] Duke Univ, Durham, NC USA

[13] Dana Farber Canc Inst, Boston, MA 02115 USA

[14] Sydney Childrens Hosp, Sydney, NSW, Australia

[15] Primary Childrens Med Ctr, Salt Lake City, UT 84103 USA

[16] Univ Cincinnati, Inst Canc, Cincinnati, OH USA

[17] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

PEDIATRIC BLOOD & CANCER | 2014年 / 61卷 / 06期

关键词：

acute lymhoblastic leukemia; Down syndrome; hematopoietic stem cell transplantation; pediatric; relapse; trisomy; 21; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; TOXICITY; FAILURE; REGIMEN; RELAPSE;

D O I：

10.1002/pbc.24918

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received myeloablative conditioning and 52% underwent transplantation in second remission. Disease-free survival (DFS) was 24% at a median of 3 years. Post-transplant leukemic relapse was more frequent than expected for children with DS-ALL (54%) than for non-DS ALL. These data suggest leukemic relapse rather than transplant toxicity is the most important cause of treatment failure. Advancements in leukemia control are especially needed for improvement in HCT outcomes for DS-ALL. Pediatr Blood Cancer 2014;61:1126-1128. (c) 2014 Wiley Periodicals, Inc.

引用

页码：1126 / 1128

页数：3

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