Spaceflight induced changes in the human proteome

被引：22
|
作者：
Kononikhin, Alexey S. [1 ,2 ,4 ]
Starodubtseva, Natalia L. [2 ,3 ,4 ]
Pastushkova, Lyudmila Kh. [1 ]
Kashirina, Daria N. [1 ]
Fedorchenko, Kristina Yu. [5 ]
Brhozovsky, Alexander G. [1 ]
Popov, Igor A. [2 ,3 ,4 ]
Larina, Irina M. [1 ]
Nikolaev, Evgeny N. [4 ,5 ,6 ]
机构：
[1] Russian Acad Sci, Lab Prote, Inst Biomed Problems, Russian Federat State Sci Res Ctr, Moscow, Russia
[2] Moscow Inst Phys & Technol, Lab Ion & Mol Phys, Moscow, Russia
[3] Minist Healthcare Russian Federat, VI Kulakov Res Ctr Obstet Gynecol & Perinatol, Lab Prote & Metabol, Moscow, Russia
[4] Russian Acad Sci, VL Talrose Inst Energy Problems Chem Phys, Lab Ion & Mol Phys, Moscow, Russia
[5] Russian Acad Sci, Emanuel Inst Biochem Phys, Moscow, Russia
[6] Skolkovo Inst Sci & Technol, Space Cluster, Skolkovo, Russia
来源：
EXPERT REVIEW OF PROTEOMICS | 2017年 / 14卷 / 01期
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
Spaceflight; proteomics; extreme conditions; human proteome; MARS; 500; bed rest study; dry immersion; microgravity; spaceflight simulation; EXHALED BREATH CONDENSATE; TERM BED REST; SPACE-FLIGHT; INTERMITTENT HYPOXIA; URINARY METABOLOME; GENE-EXPRESSION; MASS-SPECTROMETRY; PHYSICAL-ACTIVITY; HEALTHY-HUMAN; BONE LOSS;
D O I：
10.1080/14789450.2017.1258307
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Introduction: Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to minimize risks to astronauts. Areas covered: This review is a summary of literature searches from PubMed, NASA, Roskosmos and the authors' research experiences and opinions. The review covers the available proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based model experiments. Expert commentary: Overall, the authors believe that the present background, methodology and equipment improvements will enhance spaceflight safety and support accumulation of new knowledge on how organisms adapt to extreme conditions.
引用
收藏
页码：15 / 29
页数：15
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