The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo

被引：102
作者：
Brennan, C [1 ]
Rivas-Plata, K [1 ]
Landis, SC [1 ]
机构：
[1] NINDS, Neural Dev Sect, NIH, Bethesda, MD 20892 USA
来源：
NATURE NEUROSCIENCE | 1999年 / 2卷 / 08期
关键词：
D O I：
10.1038/11158
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To determine the role of the p75 neurotrophin receptor (p75(NTR)) in sympathetic neuron development, we crossed transgenic mice with mutations in p75(NTR), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Neuron number is normal in sympathetic ganglia of adult p75(NTR-/-) mice. Mice heterozygous for a NGF deletion (NGF(+/-)) have 50% fewer sympathetic neurons. In the absence of p75(NTR) (P75(NTR-/-) NGF(+/-)), however, neuron number is restored to wild-type levels. When NT-3 levels are reduced (p75(NTR-/-) NGF(+/-) NT3(+/-)), neuron number decreases compared to p75(NTR-/-) NGF(+/-) NT3(+/+). Thus, without p75(NTR), NT3 substitutes for NGF, suggesting that p75 alters the neurotrophin specificity of TrkA in vivo.
引用
收藏
页码：699 / 705
页数：7
相关论文
共 51 条
[1]   OVEREXPRESSION OF NERVE GROWTH-FACTOR IN EPIDERMIS OF TRANSGENIC MICE CAUSES HYPERTROPHY OF THE PERIPHERAL NERVOUS-SYSTEM [J].
ALBERS, KM ;
WRIGHT, DE ;
DAVIS, BM .
JOURNAL OF NEUROSCIENCE, 1994, 14 (03) :1422-1432
[2]   Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation [J].
Albers, KM ;
Perrone, TN ;
Goodness, TP ;
Jones, ME ;
Green, MA ;
Davis, BM .
JOURNAL OF CELL BIOLOGY, 1996, 134 (02) :487-497
[3]   The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death [J].
Bamji, SX ;
Majdan, M ;
Pozniak, CD ;
Belliveau, DJ ;
Aloyz, R ;
Kohn, J ;
Causing, CG ;
Miller, FD .
JOURNAL OF CELL BIOLOGY, 1998, 140 (04) :911-923
[4]   p75NTR:: A study in contrasts [J].
Barker, PA .
CELL DEATH AND DIFFERENTIATION, 1998, 5 (05) :346-356
[5]   THE P75 NERVE GROWTH-FACTOR RECEPTOR MEDIATES SURVIVAL OR DEATH DEPENDING ON THE STAGE OF SENSORY NEURON DEVELOPMENT [J].
BARRETT, GL ;
BARTLETT, PF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6501-6505
[6]   NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis [J].
Belliveau, DJ ;
Krivko, I ;
Kohn, J ;
Lachance, C ;
Pozniak, C ;
Rusakov, D ;
Kaplan, D ;
Miller, FD .
JOURNAL OF CELL BIOLOGY, 1997, 136 (02) :375-388
[7]   DIFFERENTIAL EXPRESSION OF NERVE GROWTH-FACTOR RECEPTORS LEADS TO ALTERED BINDING-AFFINITY AND NEUROTROPHIN RESPONSIVENESS [J].
BENEDETTI, M ;
LEVI, A ;
CHAO, MV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (16) :7859-7863
[8]   Analysis of cutaneous sensory neurons in transgenic mice lacking the low affinity neurotrophin receptor p75 [J].
Bergmann, I ;
Priestley, JV ;
McMahon, SB ;
Brocker, EB ;
Toyka, KV ;
Koltzenburg, M .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (01) :18-28
[9]   Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR [J].
Bibel, M ;
Hoppe, E ;
Barde, YA .
EMBO JOURNAL, 1999, 18 (03) :616-622
[10]  
BOTHWELL M, 1995, ANNU REV NEUROSCI, V18, P223, DOI 10.1146/annurev.ne.18.030195.001255
123456