Visible-Light Photoredox Decarboxylation of Perfluoroarene Iodine(III) Trifluoroacetates for C-H Trifluoromethylation of (Hetero)arenes

被引：117

作者：

Yang, Bin ^{[1
]}

Yu, Donghai ^{[2
]}

Xu, Xiu-Hua ^{[1
]}

Qing, Feng-Ling ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Organofluorine Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 North Renmin Lu, Shanghai 201620, Peoples R China

[3] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ China, Coll Chem & Chem Engn, Changsha 410081, Hunan, Peoples R China

来源：

ACS CATALYSIS | 2018年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

trifluoromethylation; photocatalysis; decarboxylation; trifluoroacetic acid; iodine(III) reagent; ALPHA-OXOCARBOXYLIC ACIDS; AROMATIC-COMPOUNDS; CARBOXYLIC-ACIDS; KETO ACIDS; PERFLUOROALKYLATION; ALKENES; CATALYSIS; REAGENTS; FUNCTIONALIZATION; DRIVEN;

D O I：

10.1021/acscatal.7b03990

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A scalable and operationally simple decarboxylative trifluoromethylation of (hetero)arenes with easily accessible C6F5I(OCOCF3)(2) under photoredox catalysis has been developed. This method is tolerant of various (hetero)-arenes and functional groups. Notably, C6F5I is recycled from the decarboxylation reaction and further used for the preparation of C6F5I(OCOCF3)(2). The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the application of trifluoroacetic acid in trifluoromethylation reactions.

引用

页码：2839 / 2843

页数：9