Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

被引：16

作者：

Xie, Qiang ^{[1
,2
]}

Liu, Shenggui ^{[1
,3
]}

Li, Xiaoling ^{[1
]}

Wu, Qiong ^{[1
]}

Luo, Zuandi ^{[1
]}

Fu, Xiaoyan ^{[1
]}

Cao, Wenqiang ^{[1
]}

Lan, Guoqiang ^{[1
]}

Li, Dan ^{[4
]}

Zheng, Wenjie ^{[1
]}

Chen, Tianfeng ^{[1
]}

机构：

[1] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

[2] Wu Jing Zong Dui Hosp Guangdong Prov, Guangzhou, Guangdong, Peoples R China

[3] Zhanjiang Normal Univ, Dept Chem Sci & Technol, Zhanjiang 524048, Peoples R China

[4] Shantou Univ, Dept Chem, Shantou 515063, Guangdong, Peoples R China

来源：

DALTON TRANSACTIONS | 2014年 / 43卷 / 19期

关键词：

DNA-BINDING; ANTIPROLIFERATIVE ACTIVITY; CELLULAR UPTAKE; CANCER-CELLS; DERIVATIVES; APOPTOSIS; CYTOTOXICITY; FLUORESCENCE; COPPER(II); MELANOMA;

D O I：

10.1039/c4dt00198b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.

引用

页码：6973 / 6976

页数：4

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