Synthetic approaches to enantiomerically pure 8-azabicyclo[3.2.1]octane derivatives

被引:91
|
作者
Pollini, Gian P.
Benetti, Simonetta
De Risi, Carmela
Zanirato, Vinicio
机构
[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy
[2] Univ Ferrara, Dipartimento Chim, I-44100 Ferrara, Italy
关键词
D O I
10.1021/cr050995+
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The tropane alkaloid family contains a large array of natural products sharing a common 8-azobicyclo[3.2.1]octane skeleton, endowed with numerous remarkable biological activities. Substances in this family have been traditionally known and used for centuries in folk medicine. Since the middle of the 19th century, the elucidation of their structure and their synthesis have contributed to no small degree to the development of organic chemistry. Given the diverse range of activities displayed by molecules based on the tropane framework, the discovery of new and interesting properties displayed by analogues based on this framework is predictable.
引用
收藏
页码:2434 / 2454
页数:21
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