Synthetic approaches to enantiomerically pure 8-azabicyclo[3.2.1]octane derivatives

The tropane alkaloid family contains a large array of natural products sharing a common 8-azobicyclo[3.2.1]octane skeleton, endowed with numerous remarkable biological activities. Substances in this family have been traditionally known and used for centuries in folk medicine. Since the middle of the 19th century, the elucidation of their structure and their synthesis have contributed to no small degree to the development of organic chemistry. Given the diverse range of activities displayed by molecules based on the tropane framework, the discovery of new and interesting properties displayed by analogues based on this framework is predictable.