Alkylating ability of artemisinin after Cu(I)-induced activation

被引：8
作者：
Bousejra-El Garah, Fatima [1 ]
Pitie, Marguerite [1 ]
Vendier, Laure [1 ]
Meunier, Bernard [2 ]
Robert, Anne [1 ]
机构：
[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France
[2] Palumed, F-31320 Castanet Tolosan, France
来源：
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2009年 / 14卷 / 04期
关键词：
Alkylation; Artemisinin; Copper; Malaria; Non-heme complexes; ANTIMALARIAL-DRUG ARTEMISININ; QINGHAOSU ARTEMISININ; STRUCTURAL-CHARACTERIZATION; PLASMODIUM-FALCIPARUM; HEME MODEL; COPPER; REDUCTION; COMPLEXES; DERIVATIVES; DECOMPOSITION;
D O I：
10.1007/s00775-009-0474-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin-copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is similar to that of Fe(II) analogues, even though the reaction is more sluggish and product distribution slightly different.
引用
收藏
页码：601 / 610
页数：10
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