Differentiation of transitional zone prostate cancer from benign hyperplasia nodules: Evaluation of discriminant criteria at multiparametric MRI

被引:79
作者
Chesnais, A. L. [1 ]
Niaf, E. [2 ]
Bratan, F. [3 ]
Mege-Lechevallier, F. [1 ]
Roche, S. [4 ]
Rabilloud, M. [4 ,5 ,6 ,7 ]
Colombel, M. [5 ,6 ,8 ]
Rouviere, O. [2 ,3 ,5 ,6 ]
机构
[1] Hosp Civils Lyon, Hop Edouard Herriot, Dept Pathol, Lyon, France
[2] INSERM, LabTau, U1032, F-69008 Lyon, France
[3] Hosp Civils Lyon, Hop Edouard Herriot, Dept Urinary & Vasc Radiol, Lyon, France
[4] Hosp Civils Lyon, Dept Biostat, Lyon, France
[5] Univ Lyon, Lyon, France
[6] Univ Lyon 1, Fac Med Lyon Est, F-69365 Lyon, France
[7] CNRS, Lab Biostat Sante, UMR 5558, Pierre Benite, France
[8] Hosp Civils Lyon, Hop Edouard Herriot, Dept Urol, Lyon, France
关键词
CONTRAST-ENHANCED MRI; COMPUTER-AIDED DIAGNOSIS; PERIPHERAL ZONE; B VALUES; LOCALIZATION; TISSUE; HISTOPATHOLOGY; PERFUSION; PATTERNS; SPREAD;
D O I
10.1016/j.crad.2013.01.018
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
AIM: To assess topographical and magnetic resonance imaging (MRI) features in characterizing prostate transitional zone (TZ) nodules. MATERIALS AND METHODS: Two radiologists evaluated all TZ nodules visible at multiparametric MRI in 52 consecutive patients who underwent radical prostatectomy. The radiologists assessed topographical (anteroposterior and superior-inferior location, crossing of the sagittal midline) and T2-weighted ( shape, presence and distinctness of capsule, distinctness of contours, presence of cysts) features, the apparent diffusion coefficient (ADC), and eight semi-quantitative and quantitative enhancement parameters derived from dynamic contrast-enhanced (DCE) imaging. The nature of the nodules was assessed using prostatectomy specimens. Five statistical methods taking into account multiple testing were used. RESULTS: One hundred and thirty-seven nodules (117 benign, 20 malignant) were evaluated. Mean ADC, all topographical, and all T2-weighted features were significant predictors of malignancy according to at least four out of the five statistical methods. Particularly, 20/20 and 18/20 cancers involved the anterior and apical third of the TZ, respectively. None of the enhancement parameters was significantly different between cancers and benign nodules. By assessing the presence of cysts, the nodules' capsule, and their anteroposterior and superior-inferior location, 111/117 benign nodules were correctly diagnosed, without misclassifying any cancer. CONCLUSION: Topographical, T2-weighted, and diffusion-weighted features can be used to characterize TZ nodules. DCE imaging does not seem to provide additional information. (C) 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:E323 / E330
页数:8
相关论文
共 33 条
[1]   Is it time to consider a role for MRI before prostate biopsy? [J].
Ahmed, Hashim U. ;
Kirkham, Alex ;
Arya, Manit ;
Illing, Rowland ;
Freeman, Alex ;
Allen, Clare ;
Emberton, Mark .
NATURE REVIEWS CLINICAL ONCOLOGY, 2009, 6 (04) :197-206
[2]   Transition zone prostate cancers: Features, detection, localization, and staging at endorectal MR imaging [J].
Akin, Oguz ;
Sala, Evis ;
Moskowitz, Chaya S. ;
Kuroiwa, Kentaro ;
Ishill, Nicole M. ;
Pucar, Darko ;
Scardino, Peter T. ;
Hricak, Hedvig .
RADIOLOGY, 2006, 239 (03) :784-792
[3]  
[Anonymous], 2008, SAS/STAT 9.2 user's guide
[4]   ESUR prostate MR guidelines 2012 [J].
Barentsz, Jelle O. ;
Richenberg, Jonathan ;
Clements, Richard ;
Choyke, Peter ;
Verma, Sadhna ;
Villeirs, Geert ;
Rouviere, Olivier ;
Logager, Vibeke ;
Futterer, Jurgen J. .
EUROPEAN RADIOLOGY, 2012, 22 (04) :746-757
[5]   Transition Zone and Anterior Stromal Prostate Cancers: Zone of Origin and Intraprostatic Patterns of Spread at Histopathology [J].
Bouye, Sebastien ;
Potiron, Eric ;
Puech, Philippe ;
Leroy, Xavier ;
Lemaitre, Laurent ;
Villers, Arnauld .
PROSTATE, 2009, 69 (01) :105-113
[6]  
Bratan F, EUR RADIOL IN PRESS
[7]   Discrimination of prostate cancer from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging [J].
Engelbrecht, MR ;
Huisman, HJ ;
Laheij, RJF ;
Jager, GJ ;
van Leenders, GJLH ;
Hulsbergen-Van De Kaa, CA ;
de la Rosette, JJMCH ;
Blickman, JG ;
Barentsz, JO .
RADIOLOGY, 2003, 229 (01) :248-254
[8]   Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging [J].
Fuetterer, Jurgen J. ;
Heijmink, Stijn W. T. P. J. ;
Scheenen, Tom W. J. ;
Veltman, Jeroen ;
Huisman, Henkjan J. ;
Vos, Pieter ;
Hulsbergen-Van de Kaa, Christina A. ;
Witjes, J. Alfred ;
Krabbe, Paul F. M. ;
Heerschap, Arend ;
Barentsz, Jelle O. .
RADIOLOGY, 2006, 241 (02) :449-458
[9]   Prostate dynamic contrast-enhanced MRI with simple visual diagnostic criteria:: is it reasonable? [J].
Girouin, Nicolas ;
Mege-Lechevallier, Florence ;
Senes, Alejandro Tonina ;
Bissery, Alvine ;
Rabilloud, Muriel ;
Marechal, Jean-Marie ;
Colombel, Marc ;
Lyonnet, Denis ;
Rouviere, Olivier .
EUROPEAN RADIOLOGY, 2007, 17 (06) :1498-1509
[10]   Transition Zone Prostate Cancer: Detection and Localization with 3-T Multiparametric MR Imaging [J].
Hoeks, Caroline M. A. ;
Hambrock, Thomas ;
Yakar, Derya ;
de Kaa, Christina A. Hulsbergen-van ;
Feuth, Ton ;
Witjes, J. Alfred ;
Futterer, Jurgen J. ;
Barentsz, Jelle O. .
RADIOLOGY, 2013, 266 (01) :207-217