Systems approaches to human autoimmune diseases

被引：12

作者：

Banchereau, Romain ^{[1
]}

Cepika, Alma-Martina ^{[1
]}

Pascual, Virginia ^{[1
,2
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

[2] Texas Scottish Rite Hosp Children, Dallas, TX 75219 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2013年 / 25卷 / 05期

关键词：

GENOME-WIDE ASSOCIATION; RHEUMATOID-ARTHRITIS; DNA METHYLATION; I INTERFERON; SYNOVIAL FIBROBLASTS; MASS CYTOMETRY; GENETIC RISK; LUPUS; EXPRESSION; MICRORNA;

D O I：

10.1016/j.coi.2013.08.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic autoimmune diseases result from interactions between genes and environmental triggers that lead to dysregulation of both innate and adaptive immunity. Systems biology approaches enable the global characterization of complex systems at the DNA, RNA and protein levels. Recent technological breakthroughs such as deep sequencing or high-throughput proteomics are revealing novel inflammatory pathways involved in autoimmunity. Herein, we review recent developments, challenges and promising avenues in the use of systems approaches to understand human systemic autoimmune and autoinflammatory diseases.

引用

页码：598 / 605

页数：8

共 94 条

[1] Genetics of monogenic autoinflammatory diseases: past successes, future challenges [J].

Aksentijevich, Ivona ;

Kastner, Daniel L. .

NATURE REVIEWS RHEUMATOLOGY, 2011, 7 (08) :468-477

[2] Urinary MicroRNA Profiling in the Nephropathy of Type 1 Diabetes [J].

Argyropoulos, Christos ;

Wang, Kai ;

McClarty, Sara ;

Huang, David ;

Bernardo, Jose ;

Ellis, Demetrius ;

Orchard, Trevor ;

Galas, David ;

Johnson, John .

PLOS ONE, 2013, 8 (01)

[3] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[4] Host Immune Transcriptional Profiles Reflect the Variability in Clinical Disease Manifestations in Patients with Staphylococcus aureus Infections [J].

Banchereau, Romain ;

Jordan-Villegas, Alejandro ;

Ardura, Monica ;

Mejias, Asuncion ;

Baldwin, Nicole ;

Xu, Hui ;

Saye, Elizabeth ;

Rossello-Urgell, Jose ;

Phuong Nguyen ;

Blankenship, Derek ;

Creech, Clarence B. ;

Pascual, Virginia ;

Banchereau, Jacques ;

Chaussabel, Damien ;

Ramilo, Octavio .

PLOS ONE, 2012, 7 (04)

[5] The genetics of autoimmune diseases: a networked perspective [J].

Baranzini, Sergio E. .

CURRENT OPINION IN IMMUNOLOGY, 2009, 21 (06) :596-605

[6] Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes [J].

Barrett, Jeffrey C. ;

Clayton, David G. ;

Concannon, Patrick ;

Akolkar, Beena ;

Cooper, Jason D. ;

Erlich, Henry A. ;

Julier, Cecile ;

Morahan, Grant ;

Nerup, Jorn ;

Nierras, Concepcion ;

Plagnol, Vincent ;

Pociot, Flemming ;

Schuilenburg, Helen ;

Smyth, Deborah J. ;

Stevens, Helen ;

Todd, John A. ;

Walker, Neil M. ;

Rich, Stephen S. .

NATURE GENETICS, 2009, 41 (06) :703-707

[7] An autoimmune disease prevented by anti-retroviral drugs [J].

Beck-Engeser, Gabriele B. ;

Eilat, Dan ;

Wabl, Matthias .

RETROVIROLOGY, 2011, 8 :91

[8] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[9] A twin approach to unraveling epigenetics [J].

Bell, Jordana T. ;

Spector, Tim D. .

TRENDS IN GENETICS, 2011, 27 (03) :116-125

[10] Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum [J].

Bendall, Sean C. ;

Simonds, Erin F. ;

Qiu, Peng ;

Amir, El-ad D. ;

Krutzik, Peter O. ;

Finck, Rachel ;

Bruggner, Robert V. ;

Melamed, Rachel ;

Trejo, Angelica ;

Ornatsky, Olga I. ;

Balderas, Robert S. ;

Plevritis, Sylvia K. ;

Sachs, Karen ;

Pe'er, Dana ;

Tanner, Scott D. ;

Nolan, Garry P. .

SCIENCE, 2011, 332 (6030) :687-696

← 1 2 3 4 5 6 7 8 9 10 →