A chemical study of cyclic depsipeptides produced by a sponge-derived fungus

被引：47

作者：

Amagata, Taro

Morinaka, Brandon I.

Amagata, Akiko

Tenney, Karen

Valeriote, Frederick A.

Lobkovsky, Emil

Clardy, Jon

Crews, Phillip ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA

[3] Henry Ford Hlth Syst, Dept Internal Med, Div Hematol & Oncol, Detroit, MI 48202 USA

[4] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

[5] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 11期

关键词：

D O I：

10.1021/np060178k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel cyclic depsipeptides, guangomides A (1) and B (2), together with a new destruxin derivative ( 3) were isolated from the cytotoxic extract obtained from the saltwater culture of an unidentifiable sponge-derived fungus. The new structures were elucidated on the basis of analysis of extensive 1D and 2D NMR data sets, and the absolute configurations of 2S, 9S, 13S, 19S, 24R, 28R of 1 were determined on the basis of the combined X-ray and Marfey's method structure analysis. Identical absolute configurations were assumed for 2. The cytotoxicity of the extract was found to be due to brefeldin A, while 1 and 2 showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans.

引用

页码：1560 / 1565

页数：6

共 30 条

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