Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism

被引:53
|
作者
Kobayashi, Junji [1 ]
Miyashita, Kazuya [2 ]
Nakajima, Katsuyuki [3 ]
Mabuchi, Hiroshi [4 ]
机构
[1] Kanazawa Med Univ Gen Internal Med, Kanazawa, Ishikawa 9200293, Japan
[2] Immunobiol Labs Co Ltd, Fujioka, Gunma, Japan
[3] Gunma Univ, Grad Sch Med, Dept Clin Lab Med, Maebashi, Gunma 371, Japan
[4] Kanazawa Univ, Grad Sch Pharmaceut Hlth Sci, Lipid Res Course, Kanazawa, Ishikawa, Japan
关键词
HDL; EL; LPL; HL deficiency; Atherosclerosis; CHYLOMICRON REMNANT-REMOVAL; HIGH-DENSITY-LIPOPROTEINS; HORMONE-SENSITIVE LIPASE; CORONARY-ARTERY-DISEASE; ESTER TRANSFER PROTEIN; ENDOTHELIAL LIPASE; TRIGLYCERIDE LIPASE; FATTY LIVER; IN-VIVO; PROMOTER POLYMORPHISM;
D O I
10.5551/jat.31617
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Hepatic lipase (HL) is a key enzyme catalyzing the hydrolysis of triglycerides (TG) and phospholipids (PLs) in several lipoproteins. It is generally recognized that HL is involved in the remodeling of remnant, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and the production of small, dense low-density lipoproteins (sd-LDLs). On the other hand, it is unclear whether HL accelerates or retards atherosclerosis. From the clinical point of view, HL deficiency may provide useful information on answering this question, but the rarity of this disease makes it impossible to conduct epidemiological study. In this review, we describe a comprehensive and updated view of the clinical significance of HL on lipid and lipoprotein metabolism.
引用
收藏
页码:1001 / 1011
页数:11
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