Biotinylated CdSe/ZnSe nanocrystals for specific fluorescent labeling

被引：31

作者：

Charvet, N

Reiss, P

Roget, A

Dupuis, A

Grünwald, D

Carayon, S

Chandezon, F

Livache, T

机构：

[1] CEA Grenoble, Dept Rech Fondamentale Mat Condensee, F-38054 Grenoble, France

[2] CEA Grenoble, Dept Reponse & Dynam Cellulaires, F-38054 Grenoble, France

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2004年 / 14卷 / 17期

关键词：

D O I：

10.1039/b403714f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A set of two new surface ligands is presented for the preparation of water-soluble, biotinylated CdSe/ZnSe core/shell nanocrystals, suitable for fluorescent biological labeling. It consists of a thiolated diethyleneglycol derivative and an alkylthiol substituted biotin molecule, which replace the initial capping ligands at the nanocrystal surface. Successful ligand exchange and long-term photostability of the modified nanocrystals as well as their highly specific binding to neuronal cells are demonstrated in different labeling experiments.

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页码：2638 / 2642

页数：5

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