Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

被引：189

作者：

Wu, CJ

Jan, JT

Chen, CM

Hsieh, HP

Hwang, DR

Liu, HW

Liu, CY

Huang, HW

Chen, SC

Hong, CF

Lin, RK

Chao, YS

Hsu, JTA

机构：

[1] Natl Hlth Res Inst, Div Biotechnol & Pharmaceut Res, Taipei, Taiwan

[2] Natl Def Univ, Natl Def Med Coll, Inst Prevent Med, Taipei, Taiwan

[3] Anim Technol Inst Taiwan, Miaoli, Taiwan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 07期

关键词：

D O I：

10.1128/AAC.48.7.2693-2696.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 muM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

引用

页码：2693 / 2696

页数：4

共 9 条

[1]

Centers for Disease Control and Prevention (CDC), 2003, MMWR-MORBID MORTAL W, V52, P570

[2] USE OF AN AQUEOUS SOLUBLE TETRAZOLIUM FORMAZAN ASSAY FOR CELL-GROWTH ASSAYS IN CULTURE [J].

CORY, AH ;

OWEN, TC ;

BARLTROP, JA ;

CORY, JG .

CANCER COMMUNICATIONS, 1991, 3 (07) :207-212

[3] ANTHELMINTICS [J].

KATZ, M .

DRUGS, 1977, 13 (02) :124-136

[4] A novel coronavirus associated with severe acute respiratory syndrome [J].

Ksiazek, TG ;

Erdman, D ;

Goldsmith, CS ;

Zaki, SR ;

Peret, T ;

Emery, S ;

Tong, SX ;

Urbani, C ;

Comer, JA ;

Lim, W ;

Rollin, PE ;

Dowell, SF ;

Ling, AE ;

Humphrey, CD ;

Shieh, WJ ;

Guarner, J ;

Paddock, CD ;

Rota, P ;

Fields, B ;

DeRisi, J ;

Yang, JY ;

Cox, N ;

Hughes, JM ;

LeDuc, JW ;

Bellini, WJ ;

Anderson, LJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) :1953-1966

[5] A major outbreak of severe acute respiratory syndrome in Hong Kong [J].

Lee, N ;

Hui, D ;

Wu, A ;

Chan, P ;

Cameron, P ;

Joynt, GM ;

Ahuja, A ;

Yung, MY ;

Leung, CB ;

To, KF ;

Lui, SF ;

Szeto, CC ;

Chung, S ;

Sung, JJY .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) :1986-1994

[6]

Leung WK, 2003, GASTROENTEROLOGY, V125, P1011, DOI [10.1053/S0016-5085(03)01215-0, 10.1016/j.gastro.2003.08.001]

[7] Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study [J].

Peiris, JSM ;

Chu, CM ;

Cheng, VCC ;

Chan, KS ;

Hung, IFN ;

Poon, LLM ;

Law, KI ;

Tang, BSF ;

Hon, TYW ;

Chan, CS ;

Chan, KH ;

Ng, JSC ;

Zheng, BJ ;

Ng, WL ;

Lai, RWM ;

Guan, Y ;

Yuen, KY .

LANCET, 2003, 361 (9371) :1767-1772

[8]

*WHO, 2003, B WORLD HEALTH ORGAN, V81, P384

[9]

WHO, 2003, WHO ENV HLTH TEAM RE

← 1 →