Copper-catalyzed domino synthesis of benzo[b]thiophene/imidazo[1,2-a]pyridines by sequential Ullmann-type coupling and intramolecular C(sp2)-H thiolation

被引：36

作者：

Yan, Kelu ^{[1
]}

Yang, Daoshan ^{[1
]}

Wei, Wei ^{[1
]}

Lu, Shenglei ^{[1
]}

Li, Guoqing ^{[1
]}

Zhao, Caixia ^{[1
]}

Zhang, Qingyun ^{[1
]}

Wang, Hua ^{[1
]}

机构：

[1] Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2016年 / 3卷 / 01期

基金：

中国国家自然科学基金;

关键词：

C-H BOND; ONE-POT SYNTHESIS; SUBSTITUTED BENZOTHIAZOLES; S-ALKENYLATION; ARYL HALIDES; EFFICIENT; SULFUR; THIOLS; FUNCTIONALIZATION; SULFENYLATION;

D O I：

10.1039/c5qo00311c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The copper-catalyzed double C-S bond formation via Ullmann-type S-arylation and C-H thiolation using K2S as a sulfur source is described. This novel one-step sulfur-incorporation method provides a straightforward avenue to benzo[b]thiophene and imidazo[1,2-a]pyridine frameworks.

引用

收藏

页码：66 / 70

页数：5

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