Macrophages-Mediated Delivery of Small Gold Nanorods for Tumor Hypoxia Photoacoustic Imaging and Enhanced Photothermal Therapy

被引：93
作者：
An, Lu [1 ,2 ,3 ]
Wang, Yuanyuan [1 ,2 ,3 ]
Lin, Jiaomin [1 ,2 ,3 ]
Tian, Qiwei [1 ,2 ,3 ]
Xie, Yinxiao [1 ,2 ,3 ]
Hu, Junqing [4 ]
Yang, Shiping [1 ,2 ,3 ]
机构：
[1] Shanghai Normal Univ, Key Lab Resource Chem, Minist Educ, Shanghai 200234, Peoples R China
[2] Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China
[3] Shanghai Normal Univ, Shanghai Municipal Educ Comm, Key Lab Mol Imaging Probes & Sensors, Shanghai 200234, Peoples R China
[4] Shenzhen Technol Univ, Coll Hlth Sci & Environm Engn, Shenzhen 518118, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2019年 / 11卷 / 17期
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
macrophages; gold nanorods; hypoxia; photoacoustic imaging; photothermal therapy; DRUG-DELIVERY; IN-VIVO; CANCER; NANOPARTICLES; BIODISTRIBUTION; NANOCRYSTALS; ABLATION; BUBBLES; MARKERS; PRODRUG;
D O I：
10.1021/acsami.9b00495
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Macrophage-mediated delivery of drugs or nanoparticles has great potential in cancer treatment because it can avoid interception by the immune system and cross the blood vessel barriers to reach the hypoxic regions of tumors. However, macrophage-based delivery system still faces some great challenges such as low theranostics agent loading capacity and hypoxic regions tendency in vivo. Herein, small gold nanorods (AuNRs) were used as the model theranostics agent to design a macrophage-mediated delivery system with high loading quantity for tumor hypoxia photoacoustic (PA) imaging and enhanced photothermal therapy (PTT). AuNRs modified with various thiolated poly(ethylene glycols (HS-PEG) via ligand exchange were investigated for toxicity and cell uptake by macrophages. The tumor hypoxic regions tendency of macrophage-loaded Anionic-AuNRs (Anionic-AuNRs@RAW) were verified by in vivo PA imaging and tumor sections. In vivo systemic PTT demonstrated enhanced tumor inhibition of anionic-AuNRs@RAW. This macrophage-mediated delivery system with high loading capacity could be used to enhance the effectiveness of cancer treatment.
引用
收藏
页码：15251 / 15261
页数：11
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