Chemical Biology in Drug Discovery

被引：1

作者：

Castaldi, M. Paola ^{[1
]}

Zuhl, Andrea ^{[1
]}

Ricchiuto, Piero ^{[2
]}

Hendricks, J. Adam ^{[1
]}

机构：

[1] AstraZeneca, IMED Biotech Unit, Discovery Sci, Waltham, MA 02451 USA

[2] AstraZeneca, IMED Biotech Unit, Discovery Sci, Cambridge, England

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 50: PLATFORM TECHNOLOGIES IN DRUG DISCOVERY AND VALIDATION | 2017年 / 50卷

关键词：

THERMAL SHIFT ASSAYS; TARGET ENGAGEMENT; SMALL-MOLECULE; 3-DIMENSIONAL STRUCTURE; REVERSIBLE INHIBITORS; COMPUTER-PREDICTION; LIGAND INTERACTIONS; PROFILING REVEALS; SIMILARITY SEARCH; OFF-TARGET;

D O I：

10.1016/bs.armc.2017.08.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：335 / 370

页数：36

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