Interplay between estrogen and retinoid signaling in breast cancer - Current and future perspectives

被引:11
作者
Ribeiro, Mariana P. C.
Santos, Armanda E.
Custodio, Jose B. A.
机构
[1] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3000354 Coimbra, Portugal
[2] Univ Coimbra, Fac Pharm, Biochem Lab, P-3000548 Coimbra, Portugal
关键词
Retinoids; Estrogen; Breast cancer; Proliferation; ACID-RECEPTOR-ALPHA; PHASE-II TRIAL; RAR-ALPHA; GENE-EXPRESSION; INHIBITS PROLIFERATION; RESPONSE ELEMENT; CARCINOMA CELLS; HEPATOCELLULAR-CARCINOMA; 13-CIS-RETINOIC ACID; TAMOXIFEN TREATMENT;
D O I
10.1016/j.canlet.2014.07.009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
All-trans-retinoic acid (RA) is a promising agent for breast cancer treatment, but it induces several adverse effects and the few clinical trials performed up to now in breast cancer patients have provided disappointing results. The combination of RA and antiestrogenic compounds, such as tamoxifen, synergistically decreases the proliferation of breast cancer cells and an interplay between retinoid and estrogen signaling has begun to be unraveled, turning these combinations into an appealing strategy for breast cancer treatment. This review focus on the current knowledge regarding the interplay between retinoid and estrogen signaling in breast cancer and the combinations of RA with antiestrogens, aiming their future utilization in cancer therapy. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:17 / 24
页数:8
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