Development of the human fetal testis

被引：19

作者：

O'Shaughnessy, Peter J. ^{[1
]}

Fowler, Paul A. ^{[2
]}

机构：

[1] Univ Glasgow, Coll Med Vet & Life Sci, Inst Biodivers Anim Hlth & Comparat Med, Glasgow G61 1QH, Lanark, Scotland

[2] Univ Aberdeen, Div Appl Med, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

ANNALES D ENDOCRINOLOGIE | 2014年 / 75卷 / 02期

关键词：

Human; Fetal; Liver; Testis; Steroidogenesis; Maternal smoking; DESERT-HEDGEHOG GENE; LEYDIG-CELLS; CIGARETTE-SMOKING; MATERNAL SMOKING; GERM-CELLS; EXPRESSION; PREGNANCY; ANDROGEN; HORMONE; NUMBER;

D O I：

10.1016/j.ando.2014.03.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Masculinisation and adult fertility in the male are dependent on appropriate fetal endocrine programming There is also now increasing evidence to indicate that the same mechanisms which regulate masculinisation also affect the general wellbeing of males throughout their life and, particularly, during ageing. Testosterone, secreted by the fetal testes, is the main factor regulating these processes and an understanding of fetal testis development in the human male is essential if we are to prevent adult reproductive disorders. This review focuses on what is known about human testis development and describes the effects of maternal smoking, a surrogate of possible xenotoxicant exposure on fetal testis and fetal liver function. (C) 2014 Published by Elsevier Masson SAS.

引用

页码：48 / 53

页数：6

共 46 条

[1] Activation of the aryl hydrocarbon receptor by a component of cigarette smoke reduces germ cell proliferation in the human fetal ovary [J].

Anderson, Richard A. ;

McIlwain, Luke ;

Coutts, Shiona ;

Kinnell, Hazel L. ;

Fowler, Paul A. ;

Childs, Andrew J. .

MOLECULAR HUMAN REPRODUCTION, 2014, 20 (01) :42-48

[2]

BAKER TG, 1980, J REPROD FERTIL, V60, P193

[3] The origins of the developmental origins theory [J].

Barker, D. J. P. .

JOURNAL OF INTERNAL MEDICINE, 2007, 261 (05) :412-417

[4] Number of germ cells and somatic cells in human fetal testes during the first weeks after sex differentiation [J].

Bendsen, E ;

Byskov, AG ;

Laursen, SB ;

Larsen, HPE ;

Andersen, CY ;

Westergaard, LG .

HUMAN REPRODUCTION, 2003, 18 (01) :13-18

[5] A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis [J].

Canto, P ;

Vilchis, F ;

Söderlund, D ;

Reyes, E ;

Méndez, JP .

MOLECULAR HUMAN REPRODUCTION, 2005, 11 (11) :833-836

[6] Retinoic Acid Signalling and the Control of Meiotic Entry in the Human Fetal Gonad [J].

Childs, Andrew J. ;

Cowan, Gillian ;

Kinnell, Hazel L. ;

Anderson, Richard A. ;

Saunders, Philippa T. K. .

PLOS ONE, 2011, 6 (06)

[7]

CODESAL J, 1990, J ANAT, V172, P103

[8] PROLIFERATION OF SERTOLI CELLS DURING DEVELOPMENT OF THE HUMAN TESTIS ASSESSED BY STEREOLOGICAL METHODS [J].

CORTES, D ;

MULLER, J ;

SKAKKEBAEK, NE .

INTERNATIONAL JOURNAL OF ANDROLOGY, 1987, 10 (04) :589-596

[9] Gonocytes, The Forgotten Cells of the Germ Cell Lineage [J].

Culty, Martine .

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 2009, 87 (01) :1-26

[10] Novel homozygous mutations in Desert Hedgehog gene in patients with 46,XY complete gonadal dysgenesis and prediction of its structural and functional implications by computational methods [J].

Das, Dhanjit Kumar ;

Sanghavi, Daksha ;

Gawde, Harshavardhan ;

Idicula-Thomas, Susan ;

Vasudevan, Lakshmi .

EUROPEAN JOURNAL OF MEDICAL GENETICS, 2011, 54 (06) :E529-E534

← 1 2 3 4 5 →