Differentiation of hidroacanthoma simplex from clonal seborrheic keratosis - An immunohistochemical study

被引:27
作者
Liu, HN [1 ]
Chang, YT [1 ]
Chen, CC [1 ]
机构
[1] Vet Gen Hosp, Dept Dermatol, Taipei 112, Taiwan
关键词
Hidroacanthoma simplex; clonal seborrheic keratosis; cytokeratin; Langerhans cell; melanin; eccrine poroma; poroma;
D O I
10.1097/00000372-200406000-00003
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Hidroacanthoma simplex (HS) is an uncommon poroid neoplasm confined within the epidermis. The clinical features of HS are not distinctive and histopathologically HS may be confused with clonal seborrheic keratosis (CSK) if cystic or ductal structure is not present. The purpose of our study was to differentiate HS from CSK by the immunohistochemical expressions of various cytokeratins, CEA, CD1a, and S-100 protein, as well as by the degrees of deposition of melanins and glycogen. Four cases of HS and seven cases of CSK were included in the research. In contrast with CSK, HS showed a very low density of Langerhans cells (19.9 +/- 7.7 versus 3.1 +/- 1.0 CD1a (+) cells/mm(2), P = 0.027) and sparse melanin deposition in the nests. However, HS could not be set apart from CSK by the expressions of cytokeratins. The nests of both HS and CSK showed very similar patterns of cytokeratin expression and seemed to be mainly composed of basaloid cells with focal differentiation toward epidermal suprabasal cells.
引用
收藏
页码:188 / 193
页数:6
相关论文
共 16 条
[1]  
[Anonymous], 1990, Neoplasms with Eccrine Differentiation
[2]  
Elder David, 1997, P747
[3]   ECCRINE POROMA - HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES [J].
HASHIMOTO, K ;
LEVER, WF .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1964, 43 (04) :237-248
[4]  
MEHREGAN AH, 1964, CANCER-AM CANCER SOC, V17, P609, DOI 10.1002/1097-0142(196405)17:5<609::AID-CNCR2820170510>3.0.CO
[5]  
2-L
[6]   COMPARATIVE CYTOKERATIN ANALYSIS OF SWEAT GLAND DUCTS AND ECCRINE POROMAS [J].
MOLL, I ;
MOLL, R .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 1991, 283 (05) :300-309
[7]   HIDROACANTHOMA SIMPLEX SHOWING VARIATION IN THE APPEARANCE OF TUMOR-CELLS IN DIFFERENT NESTS [J].
NAKAGAWA, T ;
INAI, M ;
YAMAMOTO, S ;
TAKAIWA, T .
JOURNAL OF CUTANEOUS PATHOLOGY, 1988, 15 (04) :238-244
[8]  
PEMICIARO C, 1994, J CUTAN PATHOL, V21, P274
[9]   CARCINOEMBRYONIC ANTIGEN IN BENIGN SWEAT GLAND TUMORS [J].
PENNEYS, NS ;
NADJI, M ;
MORALES, A .
ARCHIVES OF DERMATOLOGY, 1982, 118 (04) :225-227
[10]   HIDROACANTHOMA SIMPLEX - A REVIEW OF 15 CASES [J].
RAHBARI, H .
BRITISH JOURNAL OF DERMATOLOGY, 1983, 109 (02) :219-225