Targeting Bone Metastases with a Bispecific Anticancer and Antiangiogenic Polymer-Alendronate-Taxane Conjugate

被引：161

作者：

Miller, Keren ^{[1
]}

Erez, Rotem ^{[2
]}

Segal, Ehud ^{[1
]}

Shabat, Doron ^{[2
]}

Satchi-Fainaro, Ronit ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel

[2] Raymond & Beverly Sackler Fac Exact Sci, Sch Chem, Dept Organ Chem, Tel Aviv, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 16期

基金：

以色列科学基金会;

关键词：

angiogenesis; antitumor agents; bone metastases; nanoconjugates; polymers; DRUG-DELIVERY SYSTEMS; CATHEPSIN-B; PROSTATE-CANCER; BREAST-CANCER; HPMA COPOLYMER; BRAIN-TUMORS; PACLITAXEL; THERAPEUTICS; ANGIOGENESIS; CHEMOTHERAPY;

D O I：

10.1002/anie.200805133

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A polymer therapeutic designed for combination anticancer and antiangiogenic therapy inhibited the proliferation of prostate carcinoma cells and the proliferation, migration, and tube-formation of endothelial cells. The nanoconjugate was formed from an N-(2- hydroxypropyl)methacrylamide (HPMA) copolymer, the bisphosphonate alendronate (for bone targeting), and the chemotherapy agent paclitaxel (PTX), which is cleaved by cathepsin B (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2949 / 2954

页数：6

共 48 条

[31] Phase I/II study of biweekly paclitaxel and radiation in androgen-ablated locally advanced prostate cancer [J].

Sanfilippo, Nicholas J. ;

Taneja, Samir S. ;

Chachoua, Abraham ;

Lepor, Herbert ;

Formenti, Silvia C. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (18) :2973-2978

[32] Polymer therapeutics for cancer: Current status and future challenges [J].

Satchi-Fainaro, R ;

Duncan, R ;

Barnes, CM .

POLYMER THERAPEUTICS II: POLYMERS AS DRUGS, CONJUGATES AND GENE DELIVERY SYSTEMS, 2006, 193 (1-65) :1-65

[33] Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin [J].

Satchi-Fainaro, R ;

Mamluk, R ;

Wang, L ;

Short, SM ;

Nagy, JA ;

Feng, D ;

Dvorak, AM ;

Dvorak, HF ;

Puder, M ;

Mukhopadhyay, D ;

Folkman, J .

CANCER CELL, 2005, 7 (03) :251-261

[34] Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470 [J].

Satchi-Fainaro, R ;

Puder, M ;

Davies, JW ;

Tran, HT ;

Sampson, DA ;

Greene, AK ;

Corfas, G ;

Folkman, J .

NATURE MEDICINE, 2004, 10 (03) :255-261

[35] Targeting tumor vasculature: Reality or a dream? [J].

Satchi-Fainaro, R .

JOURNAL OF DRUG TARGETING, 2002, 10 (07) :529-533

[36] Paclitaxel poliglumex (XYOTAX™, CT-2103):: A macromolecular taxane [J].

Singer, JW .

JOURNAL OF CONTROLLED RELEASE, 2005, 109 (1-3) :120-126

[37]

Singer JW, 2003, ADV EXP MED BIOL, V519, P81

[38] IMMUNOHISTOCHEMICAL LOCALIZATION OF CATHEPSIN-B IN NEOPLASTIC HUMAN PROSTATE [J].

SINHA, AA ;

WILSON, MJ ;

GLEASON, DF ;

REDDY, PK ;

SAMENI, M ;

SLOANE, BF .

PROSTATE, 1995, 26 (04) :171-178

[39] Proteolytic-antiproteolytic balance and its regulation in carcinogenesis [J].

Skrzydlewska, Elzbieta ;

Sulkowska, Mariola ;

Koda, Mariusz ;

Sulkowski, Stanislaw .

WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (09) :1251-1266

[40] Hormone refractory prostate cancer: Management and advances [J].

Sonpavde, G ;

Hutson, TE ;

Berry, WR .

CANCER TREATMENT REVIEWS, 2006, 32 (02) :90-100

← 1 2 3 4 5 →