Therapeutic applications of closed-loop brain stimulation. Success and expectations

被引：1

作者：

Zrenner, C.

Ziemann, U. ^{[1
]}

机构：

[1] Univ Tubingen, Abt Neurol Schwerpunkt Neurovaskulare Erkrankunge, Klin Hirnforsch, D-72076 Tubingen, Germany

来源：

NERVENARZT | 2015年 / 86卷 / 12期

关键词：

Brain oscillations; Electroencephalogram; Transcranial magnetic stimulation; Deep brain stimulation; Real time; HUMAN MOTOR CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; SYNAPTIC PLASTICITY; PARKINSONS-DISEASE; RANDOMIZED-TRIAL; STATE; BURST; EEG;

D O I：

10.1007/s00115-015-4318-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The therapeutic application of brain stimulation is still limited to relatively few indications and small groups of patients due to variable efficacy. Individualization of stimulation parameters by employing a closed-loop system, i.e. synchronization of stimulation with endogenous brain activity with millisecond precision, has the potential to significantly improve the therapeutic efficacy when compared to open-loop systems. In this article the theoretical and experimental results are reviewed including first clinical trials that support the superiority of closed-loop brain stimulation, fundamental aspects in the development of closed loop methods are discussed and clinical studies which could quantify an increase in effectiveness are summarized. A significant increase in the indications for therapeutic applications of closed-loop systems is to be expected in the near future.

引用

页码：1523 / 1527

页数：5

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