Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues

被引：38

作者：

Chandrasekharan, Sanoop P. ^{[1
]}

Dhami, Anamika ^{[1
]}

Kumar, Sandeep ^{[1
]}

Mohanan, Kishor ^{[1
,2
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, India

[2] Acad Sci & Innovat Res, Ghaziabad 201002, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 45期

关键词：

ONE-POT SYNTHESIS; BESTMANN-OHIRA REAGENT; HIGHLY REGIOSELECTIVE SYNTHESIS; IN-SITU GENERATION; FULLY SUBSTITUTED PYRAZOLES; N-ALKYLATED TOSYLHYDRAZONES; BASE-MEDIATED REACTION; METAL-FREE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; 3-COMPONENT REACTION;

D O I：

10.1039/d2ob01918c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrazole is an essential structural component of many pharmaceuticals and agrochemicals. The synthesis of pyrazoles has been a subject of intense research for several decades. Many transformations are now available to conveniently access pyrazoles from readily available starting materials. Conventionally, the synthesis of pyrazoles involves the condensation reaction of hydrazines with 1,3-dicarbonyl compounds or their synthetic equivalents and 1,3-dipolar cycloaddition reactions of diazo compounds with dipolarophiles. The present review provides comprehensive information on the development of synthetic approaches to access pyrazoles via [3 + 2] cycloaddition reactions of diazo compounds and their synthetic equivalents.

引用

页码：8787 / 8817

页数：31

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