Influence of pretreatment ideal body weight percentile and albumin on prognosis of nasopharyngeal carcinoma: Long-term outcomes of 512 patients from a single institution

被引:60
|
作者
Li, Guo [1 ,2 ,3 ]
Gao, Jin [1 ,2 ]
Liu, Zhi-Gang [1 ,2 ]
Tao, Ya-Lan [1 ]
Xu, Bing-Qing [1 ]
Tu, Zi-Wei [1 ]
Zhang, Xiu-Ping [3 ]
Zeng, Mu-Sheng [1 ]
Xia, Yun-Fei [1 ,2 ]
机构
[1] Sun Yat Sen Univ, State Key Lab Oncol Southern China, Guangzhou 510060, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Ctr Canc, Dept Radiat Oncol, Guangzhou 510060, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Canc Inst & Hosp, Dept Radiat Oncol, Guangzhou, Guangdong, Peoples R China
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2014年 / 36卷 / 05期
关键词
prognosis; malnutrition; albumin; nasopharyngeal carcinoma; IBW%; SERUM-ALBUMIN; CANCER-PATIENTS; NECK-CANCER; MASS INDEX; NUTRITIONAL-STATUS; BREAST-CANCER; GROWTH-FACTOR; MALNUTRITION; SURVIVAL; HEAD;
D O I
10.1002/hed.23357
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background The purpose of this study was to investigate the relationship between pretreatment nutritional status and prognosis of nasopharyngeal carcinoma (NPC). Methods Pretreatment nutritional status was evaluated by ideal body weight percentile (IBW%) and serum albumin for 512 patients with NPC who underwent radical radiotherapy. Kaplan-Meier methods, log-rank test, and a Cox model were applied for survival analysis. Results Before radiotherapy, IBW% <90% was related to poorer overall survival (OS) and distant metastasis-free survival (DMFS; p = .031 and p = .012, respectively); albumin <= 43.0 g/L was related to poorer OS and DMFS (p < .001 and p = .042, respectively); both IBW% and albumin were independent prognostic factors for OS; those patients with IBW% Conclusion Decrease of pretreatment IBW% and albumin was related to poorer survival of NPC. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 660-666, 2014
引用
收藏
页码:660 / 666
页数:7
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