Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres

被引：151
|
作者：
Lee, Sangyeop [1 ]
Chon, Hyangah [1 ]
Lee, Moonkwon [1 ]
Choo, Jaebum [1 ]
Shin, Soon Young [2 ]
Lee, Young Han [2 ]
Rhyu, Im Joo [3 ]
Son, Sang Wook [4 ]
Oh, Chil Hwan [4 ]
机构：
[1] Hanyang Univ, Dept Appl Chem, Ansan 426791, South Korea
[2] Konkuk Univ, Dept Biomed Sci & Technol, Seoul 143701, South Korea
[3] Korea Univ, Coll Med, Dept Anat, Seoul 136705, South Korea
[4] Korea Univ, Coll Med, Dept Dermatol, Seoul 152703, South Korea
来源：
BIOSENSORS & BIOELECTRONICS | 2009年 / 24卷 / 07期
关键词：
Hollow gold nanosphere; Surface-enhanced Raman scattering; Cellular imaging; Cancer marker; Homogeneous sensing probe; LIVE CELLS; NANOPARTICLES; SPECTROSCOPIES;
D O I：
10.1016/j.bios.2008.10.018
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Anti body-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：2260 / 2263
页数：4
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