Viscosity measurement based on shear-wave laser speckle contrast analysis

被引：8

作者：

Cheng, Yi ^{[1
]}

Li, Sinan ^{[1
]}

Eckersley, Robert J. ^{[2
]}

Elson, Daniel S. ^{[3
]}

Tang, Meng-Xing ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England

[2] Kings Coll London, Dept Biomed Engn, London SE1 7EH, England

[3] Univ London Imperial Coll Sci Technol & Med, Hamlyn Ctr Robot Surg, Dept Surg & Canc, London SW7 2AZ, England

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2013年 / 18卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

shear wave; laser speckle contrast; viscosity; elasticity; acoustic radiation force; ultrasound; ACOUSTIC RADIATION FORCE; ELASTOGRAPHY; ELASTICITY; ULTRASOUND; LIVER;

D O I：

10.1117/1.JBO.18.12.121511

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tissue viscosity is correlated with tissue pathological changes and provides information for tissue characterization. In this study, we report an optical method to track continuous shear-wave propagation at centimeter depths in an optically turbid medium. Shear-wave attenuation coefficients were measured at multiple frequencies using shear-wave laser speckle contrast analysis (SW-LASCA) to quantitatively estimate tissue viscosity using the Voigt model. Shear waves were generated within tissue-mimicking phantoms by an amplitude-modulated ultrasound (modulation frequency: 100 to 600 Hz) and tracked by time-resolved laser speckle contrast difference received on a charged-coupled device camera. Averaged contrast difference over a selected time window was related to shear-wave amplitude and used to calculate the shear-wave attenuation coefficient. Phantoms of varying viscosities (0.1 and 0.3 Pa s) were studied. Attenuation coefficients for different shear-wave frequencies (100 to 600 Hz) were calculated. Derived viscosity values had a maximum standard deviation of 9%, and these values were consistent with the independent measurements reported in a previous study using non-optical methods. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：6

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