Cellular events in nicotine addiction

被引：18
作者：
Penton, Rachel E.
Lester, Robin A. J. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Neurol, Birmingham, AL 35294 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2009年 / 20卷 / 04期
关键词：
Upregulation; Desensitization; Tolerance; Ion channel; Plasticity; LONG-TERM POTENTIATION; MESSENGER-RNA EXPRESSION; MEDIAL PREFRONTAL CORTEX; VENTRAL TEGMENTAL AREA; RAT NUCLEUS-ACCUMBENS; ALPHA-CONOTOXIN-MII; NEURONAL ACETYLCHOLINE-RECEPTORS; CENTRAL-NERVOUS-SYSTEM; UP-REGULATION; DOPAMINE RELEASE;
D O I：
10.1016/j.semcdb.2009.01.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the 25 years since the observation that chronic exposure to nicotine could regulate the number and function of high affinity nicotine binding sites in the brain there has been a major effort to link alterations in nicotinic acetylcholine receptors (nAChRs) to nicotine-induced behaviors that drive the addiction to tobacco products. Here we review the proposed roles of various nAChR subtypes in the addiction process, with emphasis on how they are regulated by nicotine and the implications for understanding the cellular neurobiology of addiction to this drug. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：418 / 431
页数：14
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