Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina

被引：10

作者：

Nugroho, Alfarius Eko ^{[1
]}

Tange, Masaki ^{[1
]}

Kusakabe, Sumi ^{[1
]}

Hirasawa, Yusuke ^{[1
]}

Shirota, Osamu ^{[2
]}

Matsuno, Michiyo ^{[3
]}

Mizukami, Hajime ^{[3
]}

Tougan, Takahiro ^{[4
]}

Horii, Toshihiro ^{[5
]}

Morita, Hiroshi ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Ebara 2-4-41, Tokyo 1428501, Japan

[2] Tokushima Bunri Univ, Fac Pharmaceut Sci, Kagawa Campus,1314-1 Shido, Sanuki City, Kagawa 7692193, Japan

[3] Kochi Prefectural Makino Bot Garden, 4200-6 Godaisan, Kochi, Kochi 7818125, Japan

[4] Osaka Univ, Res Ctr Infect Dis Control, Res Inst Microbial Dis, 3-1 Yamadaoka, Suita, Osaka 5650871, Japan

[5] Osaka Univ, Res Inst Microbial Dis, Dept Malaria Vaccine Dev, 3-1 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2022年 / 76卷 / 04期

关键词：

Isopimarane diterpenoid; Chukranoids A-I; Chukrasia velutina; Meliaceae; Antimalarial activity; HEMATOLOGY ANALYZER XN-30; TABULARIS; LIMONOIDS;

D O I：

10.1007/s11418-022-01623-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A-I (1-9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A-I (1-9) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. It seems that conjugate system in the isopimarane skeleton may influence their antimalarial activity. [GRAPHICS] .

引用

页码：756 / 764

页数：9

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