Learning without performance in PKC-deficient Drosophila

被引:71
作者
Kane, NS [1 ]
Robichon, A [1 ]
Dickinson, JA [1 ]
Greenspan, RJ [1 ]
机构
[1] NYU,CTR NEURAL SCI,NEW YORK,NY 10003
关键词
D O I
10.1016/S0896-6273(00)80270-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from performance of the task. They fail to show immediate suppression of courtship but nonetheless develop normal memory of it.
引用
收藏
页码:307 / 314
页数:8
相关论文
共 59 条
[1]   PKC-GAMMA MUTANT MICE EXHIBIT MILD DEFICITS IN SPATIAL AND CONTEXTUAL LEARNING [J].
ABELIOVICH, A ;
PAYLOR, R ;
CHEN, C ;
KIM, JJ ;
WEHNER, JM ;
TONEGAWA, S .
CELL, 1993, 75 (07) :1263-1271
[2]   MODIFIED HIPPOCAMPAL LONG-TERM POTENTIATION IN PKC-GAMMA-MUTANT MICE [J].
ABELIOVICH, A ;
CHEN, C ;
GODA, Y ;
SILVA, AJ ;
STEVENS, CF ;
TONEGAWA, S .
CELL, 1993, 75 (07) :1253-1262
[3]   CHEMICALLY REINFORCED CONDITIONED COURTSHIP IN DROSOPHILA - RESPONSES OF WILD-TYPE AND THE DUNCE, AMNESIAC AND DON GIOVANNI MUTANTS [J].
ACKERMAN, SL ;
SIEGEL, RW .
JOURNAL OF NEUROGENETICS, 1986, 3 (02) :111-123
[4]  
ALLWEIS C, 1991, NEURAL BEHAV PLASTIC, P370
[5]  
[Anonymous], 1981, Statistical Tables
[6]   LEFT-HEMISPHERE DAMAGE AND SELECTIVE IMPAIRMENT OF AUDITORY VERBAL SHORT-TERM-MEMORY - A CASE-STUDY [J].
BASSO, A ;
SPINNLER, H ;
VALLAR, G ;
ZANOBIO, ME .
NEUROPSYCHOLOGIA, 1982, 20 (03) :263-274
[7]   MOLECULAR-CLONING OF LINOTTE IN DROSOPHILA - A NOVEL GENE THAT FUNCTIONS IN ADULTS DURING ASSOCIATIVE LEARNING [J].
BOLWIG, GM ;
DELVECCHIO, M ;
HANNON, G ;
TULLY, T .
NEURON, 1995, 15 (04) :829-842
[8]  
BRAND AH, 1993, DEVELOPMENT, V118, P401
[9]  
Broughton SJ, 1996, J CELL BIOCHEM, V62, P484, DOI 10.1002/(SICI)1097-4644(19960915)62:4<484::AID-JCB6>3.3.CO
[10]  
2-Z