Concentrations of Metals, β-Amyloid and Tau-Markers in Cerebrospinal Fluid in Patients with Alzheimer's Disease

被引:35
|
作者
Gerhardsson, Lars [1 ,2 ]
Blennow, Kaj [3 ]
Lundh, Thomas [4 ]
Londos, Elisabet [5 ]
Minthon, Lennart [5 ]
机构
[1] Sahlgrens Acad, Dept Occupat & Environm Med, SE-40530 Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden
[3] Sahlgrens Univ Hosp, Sect Expt Neurosci, Dept Clin Neurosci, Molndal, Sweden
[4] Univ Lund Hosp, Dept Occupat & Environm Med, S-22185 Lund, Sweden
[5] Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmo, Sweden
关键词
Alzheimer's disease; Cerebrospinal fluid; Metals; beta-Amyloid; Tau-markers; MILD COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; PLASMA; BRAIN; COPPER; MERCURY; SERUM; BETA-AMYLOID(1-42); EXPOSURE; PEPTIDE;
D O I
10.1159/000233353
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background/Aims: In this study, metal concentrations were related to the levels of well-known Alzheimer markers in cerebrospinal fluid (CSF), such as amyloid-beta (A beta), total tau (T-tau) and phosphorylated-tau (P-tau). Methods: Concentrations of 19 metals (Mg, Ca, V, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg and Pb by inductively coupled plasma-mass spectrometry) and the levels of A beta, T-tau and P-tau in CSF were determined (xMAP technology) in 264 patients with Alzheimer's disease ( AD), and in 54 healthy referents. Results: The AD subjects showed positive correlations between CSF-T-tau and CSF-P-tau versus CSF-Mn (r(s) = 0.22, p = 0.004; r(s) = 0.18, p = 0.021). CSF-T-tau, however, showed a negative correlation with CSF-Cs (r(s) = -0.17; p = 0.027). In subjects with severe AD, CSF-A beta showed a strong positive correlation with CSF-Cs (r(s) = 0.49; p = 0.026), while CSF-T-tau showed a strong negative correlation with CSF-Cs (r(s) = -0.49; p = 0.026). Also, CSF P-tau was negatively associated with CSF-Cs (r(s) = -0.41; p = 0.06). Conclusion: The different relationships between the CSF-levels of A beta and tau-markers versus the levels of CSF-Mn and CSF-Cs may be due to different binding affinity between these metals and metal binding proteins in the CSF and the surrounding brain. Copyright (c) 2009 S. Karger AG, Basel
引用
收藏
页码:88 / 94
页数:7
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