Neuroproteomics in Epilepsy: What Do We Know so Far?

被引:21
作者
do Canto, Amanda M. [1 ,2 ]
Donatti, Amanda [1 ,2 ]
Geraldis, Jaqueline C. [1 ,2 ]
Godoi, Alexandre B. [1 ,2 ]
da Rosa, Douglas C. [1 ,2 ]
Lopes-Cendes, Iscia [1 ,2 ]
机构
[1] Univ Campinas UNICAMP, Sch Med Sci, Dept Med Genet & Genom Med, Campinas, Brazil
[2] Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas, Brazil
基金
巴西圣保罗研究基金会;
关键词
mesial temporal lobe epilepsy; hippocampal sclerosis; malformations of cortical development; proteomics; epileptogenesis; seizures; TEMPORAL-LOBE EPILEPSY; ALPHA-B-CRYSTALLIN; FOCAL CORTICAL DYSPLASIA; RAT MODEL FOCUS; HOC TASK-FORCE; ANIMAL-MODELS; HIPPOCAMPAL SCLEROSIS; CONSENSUS CLASSIFICATION; SYNAPTIC REORGANIZATION; GLUTAMINE-SYNTHETASE;
D O I
10.3389/fnmol.2020.604158
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Epilepsies are chronic neurological diseases that affect approximately 2% of the world population. In addition to being one of the most frequent neurological disorders, treatment for patients with epilepsy remains a challenge, because a proportion of patients do not respond to the antiseizure medications that are currently available. This results in a severe economic and social burden for patients, families, and the healthcare system. A characteristic common to all forms of epilepsy is the occurrence of epileptic seizures that are caused by abnormal neuronal discharges, leading to a clinical manifestation that is dependent on the affected brain region. It is generally accepted that an imbalance between neuronal excitation and inhibition generates the synchronic electrical activity leading to seizures. However, it is still unclear how a normal neural circuit becomes susceptible to the generation of seizures or how epileptogenesis is induced. Herein, we review the results of recent proteomic studies applied to investigate the underlying mechanisms leading to epilepsies and how these findings may impact research and treatment for these disorders.
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页数:18
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