RIFM fragrance ingredient safety assessment, hexyl 2-methylbutyrate, CAS Registry Number 10032-15-2

被引：0

作者：

Api, A. M. ^{[1
]}

Belsito, D. ^{[2
]}

Biserta, S. ^{[1
]}

Botelho, D. ^{[1
]}

Bruze, M. ^{[3
]}

Burton, G. A., Jr. ^{[4
]}

Buschmann, J. ^{[5
]}

Cancellieri, M. A. ^{[1
]}

Dagli, M. L. ^{[6
]}

Date, M. ^{[1
]}

Dekant, W. ^{[7
]}

Deodhar, C. ^{[1
]}

Fryer, A. D. ^{[8
]}

Gadhia, S. ^{[1
]}

Jones, L. ^{[1
]}

Joshi, K. ^{[1
]}

Lapczynski, A. ^{[1
]}

Lavelle, M. ^{[1
]}

Liebler, D. C. ^{[9
]}

Na, M. ^{[1
]}

O'Brien, D. ^{[1
]}

Patel, A. ^{[1
]}

Penning, T. M. ^{[10
]}

Ritacco, G. ^{[1
]}

Rodriguez-Ropero, F. ^{[1
]}

Romine, J. ^{[1
]}

Sadekar, N. ^{[1
]}

Salvito, D. ^{[1
]}

Schultz, T. W. ^{[11
]}

Siddiqi, F. ^{[1
]}

Sipes, I. G. ^{[12
]}

Sullivan, G. ^{[1
]}

Thakkar, Y. ^{[1
]}

Tokura, Y. ^{[13
]}

Tsang, S. ^{[1
]}

机构：

[1] Res Inst Fragrance Mat Inc, 50 Tice Blvd, Woodcliff Lake, NJ 07677 USA

[2] Columbia Univ, Dept Dermatol, Member Expert Panel, Med Ctr, 161 Ft Washington Ave, New York, NY 10032 USA

[3] Malmo Univ Hosp, Dept Occupat & Environm Dermatol, Member Expert Panel, Sodra Forsmdsgatan 101,Entrance 47, SE-20502 Malmo, Sweden

[4] Univ Michigan, Member Expert Panel, Sch Nat Resources & Environmem, Dana Bldg G110,440 Church St, Ann Arbor, MI 58109 USA

[5] Fraunhofer Inst Toxicol & Expt Med, Member Expert Panel, Nacolai Fuchs Str 1, D-30625 Hannover, Germany

[6] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Member Expert Panel, Av Prof Dr Orlando Marques Paiva 87, BR-05508900 Sao Paulo, Brazil

[7] Univ Wurzburg, Dept Toxicol, Member Expert Panel, Versbacher Str 9, D-97078 Wurzburg, Germany

[8] Oregon Hlth & Sci Univ, Member Expert Panel, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[9] Vanderbilt Univ, Ctr Mol Toxicol, Dept Biochem, Member Expert Panel,Sch Med, 638 Robinson Res Bldg 2200,Pierce Ave, Nashville, TN 37232 USA

[10] Univ Penn, Ctr Excellence Environm Toxicol, Perelman Sch Med, Member Expert Panel, 1316 Biomed Res Bldg BRB II-III,421 Curie Blvd, Philadelphia, PA 19104 USA

[11] Univ Tennessee, Coll Vet Med, Dept Comparat Med, Member Expert Panel, 2407 River Dr, Knoxville, TN 37996 USA

[12] Univ Arizona, Coll Med, Dept Pharmacol, Member Expert Panel, 1501 North Campbell Ave,POB 245050, Tucson, AZ 85724 USA

[13] Hamamatsu Univ Sch Med, Dept Dermatol, Member Expert Panel, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 144卷

关键词：

Genotoxicity; Repeated dose; Developmental; and Reproductive toxicity; Skin sensitization; Phototoxicity/photoallergenicity; Local respiratory toxicity; Environmental safety; PERSONAL CARE; CONSUMER EXPOSURE; MODEL; ABSORPTION; COSMETICS; THRESHOLD; ASSAY;

D O I：

10.1016/j.fct.2020.111463

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The existing information supports the use of this material as described in this safety assessment. Hexyl 2-methylbutyrate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog hexyl isobutyrate (CAS # 2349-07-7) show that hexyl 2-methylbutyrate is not expected to be genotoxic. Data on read-across analog propyl (2S)-2-(1,1-dimethylpropoxy)-propanoate (CAS # 319002-92-1) provide a calculated MOE > 100 for the repeated dose toxicity and reproductive toxicity endpoints. Existing data do not indicate that hexyl 2-methylbutyrate is a sensitizer. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; hexyl 2-methylbutyrate is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material, and the exposure to hexyl 2-methylbutyrate is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; hexyl 2-methylbutyrate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are < 1.

引用

页数：9

共 41 条

[31] RIFM (Research Institute for Fragrance Materials Inc), 2002, 42046 RIFM
[32] RIFM (Research Institute for Fragrance Materials Inc), 1977, 1691 RIFM 1691 RIFM
[33] Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization
Roberts, David W.
Patlewicz, Grace
Kern, Petra S.
Gerberick, Frank
Kimber, Ian
Dearman, Rebecca J.
Ryan, Cindy A.
Basketter, David A.
Aptula, Aynur O.
[J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2007, 20 (07) : 1019 - 1030
[34] Extended-Connectivity Fingerprints
Rogers, David
Hahn, Mathew
[J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2010, 50 (05) : 742 - 754
[35] Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products
Safford, B.
Api, A. M.
Barratt, C.
Comiskey, D.
Ellis, G.
McNamara, C.
O'Mahony, C.
Robison, S.
Rose, J.
Smith, B.
Tozer, S.
[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2017, 86 : 148 - 156
[36] Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products
Safford, B.
Api, A. M.
Barratt, C.
Comiskey, D.
Daly, E. J.
Ellis, G.
McNamara, C.
O'Mahony, C.
Robison, S.
Smith, B.
Thomas, R.
Tozer, S.
[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2015, 72 (03) : 673 - 682
[37] Salvito DT, 2002, ENVIRON TOXICOL CHEM, V21, P1301, DOI 10.1897/1551-5028(2002)021<1301:AFFPFM>2.0.CO
[38] 2
[39] A strategy for structuring and reporting a read-across prediction of toxicity
Schultz, T. W.
Amcoff, P.
Berggren, E.
Gautier, F.
Klaric, M.
Knight, D. J.
Mahony, C.
Schwarz, M.
White, A.
Cronin, M. T. D.
[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2015, 72 (03) : 586 - 601
[40] An in silico skin absorption model for fragrance materials
Shen, Jie
Kromidas, Lambros
Schultz, Terry
Bhatia, Sneha
[J]. FOOD AND CHEMICAL TOXICOLOGY, 2014, 74 : 164 - 176

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