Signs and symptoms method in neuropsychology: A preliminary investigation of a standardized clinical interview for assessment of cognitive decline in dementia

被引:12
作者
Abbate, Carlo [1 ]
Trimarchi, Pietro Davide [2 ]
Inglese, Silvia [1 ]
Tomasini, Emanuele [2 ]
Bagarolo, Renzo [2 ]
Giunco, Fabrizio [2 ]
Cesari, Matteo [1 ,3 ]
机构
[1] IRCCS Ca Granda Osped Maggiore Policlin, Geriatr Unit, Via Lamarmora 5, I-20122 Milan, Italy
[2] Fdn IRCCS Don Carlo Gnocchi, Milan, Italy
[3] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy
关键词
Cognitive symptoms; Mental Status test; neurocognitive test; neuropsychology; signs and symptoms; ALZHEIMERS-DISEASE; NORMATIVE VALUES; HUMAN AUTONOMY; FRONTAL LOBES; MEMORY; ASSOCIATION; IMPAIRMENT; VALIDATION; GUIDELINES; BEHAVIOR;
D O I
10.1080/23279095.2019.1630626
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Psychologists usually perform a preliminary assessment of the person's cognitive status through a brief interview conducted before the formal testing. However, this exam has not yet been standardized with ad hoc recommendations in psychology literature. In this work, a standard observational NeuroPsychological Examination (NPE) designed for psychologists was proposed, and its clinical effectiveness evaluated. The NPE was administered to patients referred to a neuropsychological service in a memory clinic over a 2-year period. The NPEs of the patients with Alzheimer dementia (AD), vascular dementia (VaD), and healthy controls (HC) were retrospectively retrieved. Comparisons among the three groups were conducted. Abnormalities/signs identified during the NPE in the AD and VaD groups are more numerous compared to those reported in the HC group. About 80% of HCs show none or only one abnormal sign. Vice versa, 87.5% of both AD and VaD patients show three or more abnormalities. Accordingly, the NPE has 0.88 (95%CI = 0.81-0.95) sensitivity and 0.95 (95%CI = 0.88-1.02) specificity for detecting cognitive decline when a cut-point of three or more signs is applied. Some significant differences also emerge on the number of pathological signs between AD and VaD patients. NPE is a promising tool with demonstrated diagnostic utility in dementia patients.
引用
收藏
页码:282 / 296
页数:15
相关论文
共 58 条
[1]   Clinical neuropsychologists need a standard preliminary observational examination of cognitive functions [J].
Abbate, Carlo ;
Trimarchi, Pietro D. .
FRONTIERS IN PSYCHOLOGY, 2013, 4
[2]  
[Anonymous], 1987, Ital J Neurol Sci, VSuppl 8, P1
[3]  
[Anonymous], 2003, ENB esame neuropsicologico breve
[4]  
Basso A, 1987, Funct Neurol, V2, P189
[5]   Neuropsychological Measures that Predict Progression from Mild Cognitive Impairment to Alzheimer's type dementia in Older Adults: a Systematic Review and Meta-Analysis [J].
Belleville, Sylvie ;
Fouquet, Celine ;
Hudon, Carol ;
Zomahoun, Herve Tchala Vignon ;
Croteau, Jordie .
NEUROPSYCHOLOGY REVIEW, 2017, 27 (04) :328-353
[6]   CONFABULATION [J].
BERLYNE, N .
BRITISH JOURNAL OF PSYCHIATRY, 1972, 120 (554) :31-&
[7]   Rey-Osterrieth complex figure: normative values in an Italian population sample [J].
Caffarra, P ;
Vezzadini, G ;
Dieci, F ;
Zonato, F ;
Venneri, A .
NEUROLOGICAL SCIENCES, 2002, 22 (06) :443-447
[8]   Altered Sense of Humor in Dementia [J].
Clark, Camilla N. ;
Nicholas, Jennifer M. ;
Gordon, Elizabeth ;
Golden, Hannah L. ;
Cohen, Miriam H. ;
Woodward, Felix J. ;
Macpherson, Kirsty ;
Slattery, Catherine F. ;
Mummery, Catherine J. ;
Schott, Jonathan M. ;
Rohrer, Jonathan D. ;
Warren, Jason D. .
JOURNAL OF ALZHEIMERS DISEASE, 2016, 49 (01) :111-119
[9]  
Critchley M., 1953, The parietal lobes
[10]   Consensus classification of posterior cortical atrophy [J].
Crutch, Sebastian J. ;
Schott, Jonathan M. ;
Rabinovici, Gil D. ;
Murray, Melissa ;
Snowden, Julie S. ;
van der Flier, Wiesje M. ;
Dickerson, Bradford C. ;
Vandenberghe, Rik ;
Ahmed, Samrah ;
Bak, Thomas H. ;
Boeve, Bradley F. ;
Butler, Christopher ;
Cappa, Stefano F. ;
Ceccaldi, Mathieu ;
de Souza, Leonardo Cruz ;
Dubois, Bruno ;
Felician, Olivier ;
Galasko, Douglas ;
Graff-Radford, Jonathan ;
Graff-Radford, Neill R. ;
Hof, Patrick R. ;
Krolak-Salmon, Pierre ;
Lehmann, Manja ;
Magnin, Eloi ;
Mendez, Mario F. ;
Nestor, Peter J. ;
Onyike, Chiadi U. ;
Pelak, Victoria S. ;
Pijnenburg, Yolande ;
Primativo, Silvia ;
Rossor, Martin N. ;
Ryan, Natalie S. ;
Scheltens, Philip ;
Shakespeare, Timothy J. ;
Suarez Gonzalez, Aida ;
Tang-Wai, David F. ;
Yong, Keir X. X. ;
Carrillo, Maria ;
Fox, Nick C. .
ALZHEIMERS & DEMENTIA, 2017, 13 (08) :870-884