Does growth hormone therapy improve motor development in infants with Prader-Willi syndrome?

被引：9
作者：
Eiholzer, U
Malich, S
I'Allemand, D
机构：
[1] Fdn Growth Puberty Adolescence, CH-8006 Zurich, Switzerland
[2] Univ Zurich, Dept Pediat, Ctr Growth & Dev, CH-8006 Zurich, Switzerland
来源：
EUROPEAN JOURNAL OF PEDIATRICS | 2000年 / 159卷 / 04期
关键词：
Growth Hormone; Hormone Therapy; Motor Development; Growth Hormone Therapy;
D O I：
10.1007/s004310050075
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
In infants with Prader-Willi syndrome (PWS), only milestones of development have been retrospectively assessed so far [2, 7]. In our study on growth hormone (GH) treatment in young children with PWS, we found a typical pattern of psychomotor retardation with these children being more retarded on the 'locomotor' and the 'hearing and speech' scale than on the other scales. Under GH treatment, motor development improved significantly, while speech development did not.
引用
收藏
页码：299 / 299
页数：1
相关论文
共 7 条
[1]  
BRAND I, 1983, BEURTEILUNG ENTWICKL
[2]   PRADER-WILLI SYNDROME - CURRENT UNDERSTANDING OF CAUSE AND DIAGNOSIS [J].
BUTLER, MG .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1990, 35 (03) :319-332
[3]   Growth hormone improves body composition, fat utilization, physical strength and agility, and growth in Prader-Willi syndrome: A controlled study [J].
Carrel, AL ;
Myers, SE ;
Whitman, BY ;
Allen, DB .
JOURNAL OF PEDIATRICS, 1999, 134 (02) :215-221
[4]   Effect of growth hormone on height, weight, and body composition in Prader-Willi syndrome [J].
Davies, PSW ;
Evans, S ;
Broomhead, S ;
Clough, H ;
Day, JME ;
Laidlaw, A ;
Barnes, ND .
ARCHIVES OF DISEASE IN CHILDHOOD, 1998, 78 (05) :474-476
[5]   Treatment with human growth hormone in patients with Prader-Labhart-Willi syndrome reduces body fat and increases muscle mass and physical performance [J].
Eiholzer, U ;
Gisin, R ;
Weinmann, C ;
Kriemler, S ;
Steinert, H ;
Torresani, T ;
Zachmann, M ;
Prader, A .
EUROPEAN JOURNAL OF PEDIATRICS, 1998, 157 (05) :368-377
[6]   Body fat determined by skinfold measurements is elevated despite underweight in infants with Prader-Labhart-Willi syndrome [J].
Eiholzer, U ;
Blum, WF ;
Molinari, L .
JOURNAL OF PEDIATRICS, 1999, 134 (02) :222-225
[7]   GENOTYPE-PHENOTYPE CORRELATION IN A SERIES OF 167 DELETION AND NONDELETION PATIENTS WITH PRADER-WILLI-SYNDROME [J].
GILLESSENKAESBACH, G ;
ROBINSON, W ;
LOHMANN, D ;
KAYAWESTERLOH, S ;
PASSARGE, E ;
HORSTHEMKE, B .
HUMAN GENETICS, 1995, 96 (06) :638-643
1