Organocatalytic C-C bond activation of cyclopropenones for ring-opening formal [3+2] cycloaddition with isatins

被引：40

作者：

Xu, Junyu ^{[1
]}

Cao, Jing ^{[1
]}

Fang, Chao ^{[1
]}

Lu, Tao ^{[1
]}

Du, Ding ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Organ Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 04期

基金：

中国国家自然科学基金;

关键词：

CARBON-CARBON BOND; CARBENE-CATALYZED REACTIONS; CPCO-MEDIATED REACTIONS; DIELS-ALDER ADDUCT; ALKYNYL ALDEHYDES; ACCESS; ANNULATION; 1,3-DIPHENYLISOBENZOFURAN; DIPHENYLCYCLOPROPENONE; SPIROOXINDOLES;

D O I：

10.1039/c6qo00734a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclopropenones were first applied as potential 3C synthons in ring-opening formal cycloaddition via an organocatalytic C-C bond activation strategy. This [3 + 2] cycloaddition of cyclopropenones with isatins catalyzed by using two different Lewis bases offers rapid access to spirooxindoles 3 and 4 regioselectively. These findings will provide helpful guidelines for further investigation of the reactivity of cyclopropenones with organocatalysis.

引用

页码：560 / 564

页数：5

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