Isolation and Identification of a Potent PTP1B Inhibitor, Ursolic Acid, from Carolina Jasmine (Gelsemium sempervirens (L.) J.St.-Hil.)

被引：1

作者：

Noshita, Toshiro ^{[1
,2
]}

Kakizoe, Yusuke ^{[1
]}

Tanabe, Satoshi ^{[3
]}

Ouchi, Hidekazu ^{[4
]}

Tai, Akihiro ^{[5
]}

机构：

[1] Prefectural Univ Hiroshima, Dept Life Sci, Fac Life & Environm Sci, 5562 Nanatsuka, Hiroshima 7270023, Japan

[2] Gifu Univ Med Sci, Dept Pharm, 4-3-3 Nijigaoka, Gifu 5090293, Japan

[3] Prefectural Univ Hiroshima, Grad Sch Comprehens Sci Res, Program Biol Syst Sci, 5562 Nanatsuka, Hiroshima 7270023, Japan

[4] Kindai Univ, Fac Pharm, Dept Pharm, 3-4-1 Kowakae, Higashiosaka, Osaka 5778502, Japan

[5] Tokushima Univ, Grad Sch Technol Ind & Social Sci, 2-1 Minami Josanjima, Tokushima 7708506, Japan

来源：

LETTERS IN ORGANIC CHEMISTRY | 2020年 / 17卷 / 12期

关键词：

Protein tyrosine phosphatase 1B inhibitor; Carolina jasmine; Gelsemium sempervirens; ursolic acid; petal; Gelsemiaceae; URSANE-TYPE TRITERPENOIDS;

D O I：

10.2174/1570178617666200409101248

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Extracts of Carolina jasmine (Gelsemium sempervirens (L.) J.St.-Hil.) petals were evaluated in vitro for inhibition activity against protein tyrosine phosphatase 1B (PTP1B). The principle active agent was also isolated from the extract and identified as ursolic acid (1). This is the first report of ursolic acid from G. sempervirens and of PTP1B-inhibiting activity in the genus Gelsemium.

引用

页码：939 / 943

页数：5

共 6 条

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[6] Rapid Identification of Flavonoid Constituents Directly from PTP1B Inhibitive Extract of Raspberry (Rubus idaeus L.) Leaves by HPLC-ESI-QTOF-MS-MS
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