Stimuli-Responsive DNA Self-Assembly: From Principles to Applications

被引:24
|
作者
Yu, Yang [1 ]
Jin, Bang [1 ]
Li, Yulin [1 ]
Deng, Zhaoxiang [2 ]
机构
[1] Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
基金
中国国家自然科学基金;
关键词
biomedicine; DNA; nanostructures; self-assembly; stimuli-responsive; HYBRIDIZATION CHAIN-REACTION; PH CHANGES; TARGETED TRANSPORT; RATIONAL DESIGN; TETHERED DNA; NANOSTRUCTURES; NANOTECHNOLOGY; SURFACE; DRIVEN; NANOMACHINE;
D O I
10.1002/chem.201900491
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Stimuli-responsive DNA self-assembly shares the advantages of both designed stimuli-responsiveness and the molecular programmability of DNA structures, offering great opportunities for basic and applied research in dynamic DNA nanotechnology. In this minireview, we summarize the most recent progress in this rapidly developing field. The trigger mechanisms of the responsive DNA systems are first divided into six categories, which are then explained with illustrative examples following this classification. Subsequently, proof-of-concept applications in terms of biosensing, in vivo pH-mapping, drug delivery, and therapy are discussed. Finally, we provide some remarks on the challenges and opportunities of this highly promising research direction in DNA nanotechnology.
引用
收藏
页码:9785 / 9798
页数:14
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