Borinic acid catalysed peptide synthesis

被引：82

作者：

El Dine, Tharwat Mohy ^{[1
]}

Rouden, Jacques ^{[1
]}

Blanchet, Jerome ^{[1
]}

机构：

[1] Univ Caen Normandie, CNRS, ENSICAEN, Lab Chim Mol & Thioorgan, F-14050 Caen, France

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 89期

关键词：

AMIDE BOND FORMATION; CARBOXYLIC-ACIDS; ROOM-TEMPERATURE; DIRECT AMIDATION; COUPLING REAGENTS; BORONIC ACIDS; AMINES; DERIVATIVES; PROTODEBORONATION; DIOLS;

D O I：

10.1039/c5cc06177f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalytic synthesis of peptides is a major challenge in the modern organic chemistry hindered by the well-established use of stoichiometric coupling reagents. Herein, we describe for the first time that borinic acid is able to catalyse this reaction under mild conditions with an improved activity compared to our recently developed thiophene-based boronic acid. This catalyst is particularly efficient for peptide bond synthesis affording dipeptides in good yields without detectable racemization.

引用

页码：16084 / 16087

页数：4

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