Registration of planar bioluminescence to magnetic resonance and x-ray computed tomography images as a platform for the development of bioluminescence tomography reconstruction algorithms

被引:16
作者
Beattie, Bradley J. [1 ]
Klose, Alexander D. [2 ]
Le, Carl H. [3 ]
Longo, Valerie A. [4 ]
Dobrenkov, Konstantine [4 ]
Vider, Jelena [1 ]
Koutcher, Jason A. [3 ,4 ,5 ]
Blasberg, Ronald G. [1 ,4 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10065 USA
[2] Columbia Univ, Dept Radiol, New York, NY 10027 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10065 USA
[4] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USA
[5] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
关键词
image registration; bioluminescence tomography (BLT); retrospective; whole body; rigid body; small animal; IN-VIVO; OPTICAL TOMOGRAPHY;
D O I
10.1117/1.3120495
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The procedures we propose make possible the mapping of two-dimensional (2-D) bioluminescence image (BLI) data onto a skin surface derived from a three-dimensional (3-D) anatomical modality [magnetic resonance (MR) or computed tomography (CT)] dataset. This mapping allows anatomical information to be incorporated into bioluminescence tomography (BLT) reconstruction procedures and, when applied using sources visible to both optical and anatomical modalities, can be used to evaluate the accuracy of those reconstructions. Our procedures, based on immobilization of the animal and a priori determined fixed projective transforms, should be more robust and accurate than previously described efforts, which rely on a poorly constrained retrospectively determined warping of the 3-D anatomical information. Experiments conducted to measure the accuracy of the proposed registration procedure found it to have a mean error of 0.36 +/- 0.23 mm. Additional experiments highlight some of the confounds that are often overlooked in the BLT reconstruction process, and for two of these confounds, simple corrections are proposed. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3120495]
引用
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页数:9
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