Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet
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作者:
Cheong, J. D. Li Kwok
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
Cheong, J. D. Li Kwok
[1
]
Croft, K. D.
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
Croft, K. D.
[1
]
Henry, P. D.
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
Henry, P. D.
[1
]
Matthews, V.
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Harry Perkins Inst Med Res, UWA Ctr Med Res, Lab Metab Dysfunct, Perth, WA, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
Matthews, V.
[2
]
Hodgson, J. M.
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
Hodgson, J. M.
[1
]
Ward, N. C.
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
Ward, N. C.
[1
]
机构:
[1] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
[2] Harry Perkins Inst Med Res, UWA Ctr Med Res, Lab Metab Dysfunct, Perth, WA, Australia
We have investigated the effects of the major polyphenol in coffee, chlorogenic acid (CGA), on obesity, glucose intolerance, insulin resistance, systemic oxidative stress and endothelial dysfunction in a mouse model of the metabolic syndrome. Thirty C57BL6 mice were randomly divided into (n = 10/group) (i) normal diet (ND), (ii) high fat diet (HFD), or (iii) high fat diet supplemented with 0.5% w/w green coffee bean extract (GCE) rich in chlorogenic acid (HFD + GCE). The high fat diet consisted of 28% fat and all animals were maintained on their diets for 12 weeks. The mice fed a HFD and HFD + GCE displayed symptoms of the metabolic syndrome compared to their normal fed counterparts, although no endothelial dysfunction was detected in the abdominal aortas after 12 weeks. GCE did not attenuate HFD-induced obesity, glucose intolerance, insulin resistance or systemic oxidative stress. Furthermore, GCE did not protect against ex vivo oxidant (hypochlorous acid)-induced endothelial dysfunction. (C) 2014 Elsevier Inc. All rights reserved.
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Univ Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, AustraliaUniv Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
Bohn, Siv K.
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Ward, Natalie C.
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Univ Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, AustraliaUniv Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
Ward, Natalie C.
;
Hodgson, Jonathan M.
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Univ Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, AustraliaUniv Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
Hodgson, Jonathan M.
;
Croft, Kevin D.
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Univ Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
Univ Western Australia M570, Sch Med & Pharmacol, Perth, WA 6847, AustraliaUniv Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Bondonno, Catherine P.
;
Yang, Xingbin
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Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian, Peoples R ChinaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Yang, Xingbin
;
Croft, Kevin D.
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Croft, Kevin D.
;
Considine, Michael J.
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Univ Western Australia, Sch Plant Biol, Perth, WA 6000, Australia
Western Australia, Dept Agr & Food, S Perth, WA 6151, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Considine, Michael J.
;
Ward, Natalie C.
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Ward, Natalie C.
;
Rich, Lisa
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Rich, Lisa
;
Puddey, Ian B.
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Puddey, Ian B.
;
Swinny, Ewald
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Ctr Chem, Perth, WA 6102, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Swinny, Ewald
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Mubarak, Aidilla
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Mubarak, Aidilla
;
Hodgson, Jonathan M.
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Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
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Univ Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandUniv Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
Crozier, Thomas W. M.
;
Stalmach, Angelique
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Univ Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandUniv Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
Stalmach, Angelique
;
Lean, Michael E. J.
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Univ Glasgow, Coll Med Vet & Life Sci, Royal Infirm, Glasgow G4 0SF, Lanark, ScotlandUniv Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
Lean, Michael E. J.
;
Crozier, Alan
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Univ Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandUniv Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
机构:
Univ Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, AustraliaUniv Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
Bohn, Siv K.
;
Ward, Natalie C.
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机构:
Univ Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, AustraliaUniv Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
Ward, Natalie C.
;
Hodgson, Jonathan M.
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Univ Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, AustraliaUniv Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
Hodgson, Jonathan M.
;
Croft, Kevin D.
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机构:
Univ Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
Univ Western Australia M570, Sch Med & Pharmacol, Perth, WA 6847, AustraliaUniv Western Australia M570, Sch Med & Pharmacol, Crawley, WA 6009, Australia
机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Bondonno, Catherine P.
;
Yang, Xingbin
论文数: 0引用数: 0
h-index: 0
机构:
Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian, Peoples R ChinaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Yang, Xingbin
;
Croft, Kevin D.
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h-index: 0
机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Croft, Kevin D.
;
Considine, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Sch Plant Biol, Perth, WA 6000, Australia
Western Australia, Dept Agr & Food, S Perth, WA 6151, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Considine, Michael J.
;
Ward, Natalie C.
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机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Ward, Natalie C.
;
Rich, Lisa
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机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Rich, Lisa
;
Puddey, Ian B.
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机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Puddey, Ian B.
;
Swinny, Ewald
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机构:
Ctr Chem, Perth, WA 6102, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Swinny, Ewald
;
Mubarak, Aidilla
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h-index: 0
机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
Mubarak, Aidilla
;
Hodgson, Jonathan M.
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机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6000, AustraliaUniv Western Australia, Sch Med & Pharmacol, Perth, WA 6000, Australia
机构:
Univ Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandUniv Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
Crozier, Thomas W. M.
;
Stalmach, Angelique
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h-index: 0
机构:
Univ Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandUniv Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
Stalmach, Angelique
;
Lean, Michael E. J.
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h-index: 0
机构:
Univ Glasgow, Coll Med Vet & Life Sci, Royal Infirm, Glasgow G4 0SF, Lanark, ScotlandUniv Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
Lean, Michael E. J.
;
Crozier, Alan
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机构:
Univ Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandUniv Glasgow, Sch Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland