Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet

被引:30
作者
Cheong, J. D. Li Kwok [1 ]
Croft, K. D. [1 ]
Henry, P. D. [1 ]
Matthews, V. [2 ]
Hodgson, J. M. [1 ]
Ward, N. C. [1 ]
机构
[1] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
[2] Harry Perkins Inst Med Res, UWA Ctr Med Res, Lab Metab Dysfunct, Perth, WA, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
Chlorogenic acid; Atherosclerosis; Metabolic syndrome; Endothelial dysfunction; Coffee; E-KNOCKOUT MICE; CHLOROGENIC ACID; OXIDATIVE STRESS; PHENOLIC-COMPOUNDS; TEA CONSUMPTION; DYSFUNCTION; OBESITY; PLASMA; ATHEROSCLEROSIS; CARBOHYDRATE;
D O I
10.1016/j.abb.2014.02.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have investigated the effects of the major polyphenol in coffee, chlorogenic acid (CGA), on obesity, glucose intolerance, insulin resistance, systemic oxidative stress and endothelial dysfunction in a mouse model of the metabolic syndrome. Thirty C57BL6 mice were randomly divided into (n = 10/group) (i) normal diet (ND), (ii) high fat diet (HFD), or (iii) high fat diet supplemented with 0.5% w/w green coffee bean extract (GCE) rich in chlorogenic acid (HFD + GCE). The high fat diet consisted of 28% fat and all animals were maintained on their diets for 12 weeks. The mice fed a HFD and HFD + GCE displayed symptoms of the metabolic syndrome compared to their normal fed counterparts, although no endothelial dysfunction was detected in the abdominal aortas after 12 weeks. GCE did not attenuate HFD-induced obesity, glucose intolerance, insulin resistance or systemic oxidative stress. Furthermore, GCE did not protect against ex vivo oxidant (hypochlorous acid)-induced endothelial dysfunction. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:46 / 52
页数:7
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