Lack of an association between left-handedness and APOE polymorphism in a large sample of adults: Results of the Czech HAPIEE study

被引：8

作者：

Hubacek, Jaroslav A. ^{[1
]}

Piper, Brian J. ^{[2
]}

Pikhart, Hynek ^{[3
]}

Peasey, Anne ^{[3
]}

Kubinova, Ruzena ^{[4
]}

Bobak, Martin ^{[3
]}

机构：

[1] Inst Clin & Expt Med, Prague, Czech Republic

[2] Willamette Univ, Dept Psychol, Salem, OR 97301 USA

[3] UCL, Dept Epidemiol & Publ Hlth, London, England

[4] Natl Inst Publ Hlth, Prague, Czech Republic

来源：

LATERALITY | 2013年 / 18卷 / 05期

基金：

英国惠康基金;

关键词：

Apolipoprotein E; Handedness; Polymorphism; APOLIPOPROTEIN-E POLYMORPHISM; FAMILY HANDEDNESS; GENOTYPE; DISEASE; ALLELE; IMPACT;

D O I：

10.1080/1357650X.2012.715164

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

An association between APOE genotype and left-handedness has been previously reported. We examined whether such association exists in a population sample of 4438 unrelated Caucasian adults aged 45-69 years (2022 males and 2416 females). Left-handedness was based on self-reported left-hand dominance for writing (prevalence 4.9%) and on consistently higher left-hand grip strength in two repeated measurements (prevalence 12.2%). Individuals with higher left hand grip strength were seven times more likely to be self-reported left handers (p<.0001, (2) 159.7, 2 df). There were no differences in the proportion of self-reported left-handedness (p=.828, (2) 2.1, 5 df) or higher grip strength in left hand (p=.557, (2) 3.9, 5 df) between APOE genotypes. The lack of association was similar in both genders and did not differ by age group. The results suggest that left-handedness in adults is not related to APOE genotype.

引用

页码：513 / 519

页数：7