A new single nucleotide polymorphism in the rabbit (Oryctolagus cuniculus) myostatin (MSTN) gene is associated with carcass composition traits

被引：27
|
作者：
Sternstein, Ina [1 ]
Reissmann, Monika [1 ]
Maj, Dorota [2 ]
Bieniek, Josef [2 ]
Brockmann, Gudrun A. [1 ]
机构：
[1] Humboldt Univ, Dept Crop & Anim Sci, Fac Life Sci, D-10115 Berlin, Germany
[2] Agr Univ Krakow, Dept Genet & Anim Breeding, Fac Anim Sci, PL-30059 Krakow, Poland
来源：
ANIMAL GENETICS | 2014年 / 45卷 / 04期
关键词：
cross-bred population; gene variation; haplotype; meat quality; muscle mass; SHEEP OVIS-ARIES; MUSCLE GROWTH; MUTATION; MUSCULARITY; WEIGHT; CATTLE; PIG;
D O I：
10.1111/age.12165
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
This study aimed at the identification of genetic variations in the myostatin (MSTN) gene and testing their effects on carcass quality traits. We comparatively sequenced Giant Grey (GG) and New Zealand White (NZW) rabbits that were founders of a cross-bred population. Alignment of our sequence data with the GenBank sequence of the rabbit MSTN gene (Ensembl Gene ID ENSOCUG00000012663) identified three single nucleotide polymorphisms (SNPs). The two novel SNPs (c.-125T>C, c.373+234G>A) and one known SNP (c.747+34C>T) were subsequently analysed for linkage with carcass composition traits in 363 F-2 animals of the cross GG x NZW. Significant linkage was found between c.373+234G>A and nine carcass composition traits (P < 0.05). No significant effects were found for c.-125T>C and c.747+34C>T. Because the linked SNP is located in intron 1 and no genetic variation was found in the coding region, further investigations are necessary to understand the functional effect of the c.373+234G>A variant on the variability of the traits.
引用
收藏
页码：596 / 599
页数：4
相关论文
共 50 条
  • [41] High-resolution melting analysis for detection of a single-nucleotide polymorphism and the genotype of the myostatin gene in warmblood horses
    Serpa, Priscila B. S.
    Garbade, Petra
    Natalini, Claudio C.
    Pires, Ananda R.
    Tisotti, Tainor M.
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 2017, 78 (01) : 63 - 68
  • [42] A single nucleotide polymorphism (A→G) in intron 3 of IFNγ gene is associated with asthma
    Kumar, A.
    Ghosh, B.
    GENES AND IMMUNITY, 2008, 9 (04) : 294 - 301
  • [43] A polymorphism in the 5′-flanking region of the melanocortin-4 receptor gene is associated with carcass traits in quails
    Fu, J.
    Ning, F. Y.
    Du, Z. H.
    Yang, C. S.
    Yang, H. Y.
    Bai, X. J.
    INDIAN JOURNAL OF ANIMAL SCIENCES, 2012, 82 (03): : 299 - 303
  • [44] A single nucleotide polymorphism in NEUROD1 is associated with production traits in Nelore beef cattle
    de Oliveira, P. S. N.
    Tizioto, P. C.
    Malago, W., Jr.
    do Nascimento, M. L.
    Cesar, A. S. M.
    Diniz, W. J. S.
    de Souza, M. M.
    Lanna, D. P. D.
    Tullio, R. R.
    Mourao, G. B.
    Mudadu, M. de A.
    Coutinho, L. L.
    Regitano, L. C. de A.
    GENETICS AND MOLECULAR RESEARCH, 2016, 15 (02)
  • [45] Study on Association of Single Nucleotide Polymorphism of MC3R and MC4R Genes with Carcass and Meat Quality Traits in Chicken
    Wang, Yan
    Su, Yi
    Jiang, Xiaosong
    Liu, Yiping
    Li, Xiaocheng
    Zhang, Zengrong
    Du, Huarui
    Zhu, Qing
    JOURNAL OF POULTRY SCIENCE, 2009, 46 (03): : 180 - 187
  • [46] Gene expression profiling in skeletal muscle of Holstein-Friesian bulls with single-nucleotide polymorphism in the myostatin gene 5'-flanking region
    Sadkowski, Tomasz
    Jank, Michal
    Zwierzchowski, Lech
    Siadkowska, Eulalia
    Oprzadek, Jolanta
    Motyl, Tomasz
    JOURNAL OF APPLIED GENETICS, 2008, 49 (03) : 237 - 249
  • [47] Gene expression profiling in skeletal muscle of Holstein-Friesian bulls with single-nucleotide polymorphism in the myostatin gene 5’-flanking region
    Tomasz Sadkowski
    Michał Jank
    Lech Zwierzchowski
    Eulalia Siadkowska
    Jolanta Oprządek
    Tomasz Motyl
    Journal of Applied Genetics, 2008, 49 : 237 - 250
  • [48] Evaluating the effects of a single copy of a mutation in the myostatin gene (c.*1232G&gt;A) on carcass traits in crossbred lambs
    Masri, A. Y.
    Lambe, N. R.
    Macfarlane, J. M.
    Brotherstone, S.
    Haresign, W.
    Buenger, L.
    MEAT SCIENCE, 2011, 87 (04) : 412 - 418
  • [49] Association of a novel single nucleotide polymorphism in growth hormone receptor gene with production traits in Bali cattle
    Maskur
    Rodiah
    Arman, Chairussyuhur
    ITALIAN JOURNAL OF ANIMAL SCIENCE, 2014, 13 (04) : 841 - 844
  • [50] Effect of Single Nucleotide Polymorphism of IRF1 Gene on Cytokine Traits in Three Pig Breeds
    Liu, Y.
    Lu, X.
    Luo, Y. R.
    Zhou, J. P.
    Liu, X. Y.
    Zhang, Q.
    Yin, Z. J.
    JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2010, 9 (18): : 2346 - 2350
12345