Disruptive insights in psychiatry: transforming a clinical discipline

被引：97

作者：

Insel, Thomas R. ^{[1
]}

机构：

[1] NIMH, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; ANTIPSYCHOTIC-DRUGS; BIPOLAR DISORDER; MAJOR DEPRESSION; MENTAL-DISORDERS; NEURAL CIRCUITS; RISK LOCI; SCHIZOPHRENIA; TWIN; COMORBIDITY;

D O I：

10.1172/JCI38832

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mental disorders such as schizophrenia, bipolar illness, and depression have become the predominant chronic diseases of young people, accounting for approximately 40% of the medical burden for people aged 15-44 in the United States and Canada. Research is transforming our understanding of these disorders, as exemplified in the articles in this Review Series. Important, "disruptive" insights into pathophysiology are emerging from studies addressing these illnesses as brain disorders, developmental disorders, and complex genetic disorders - rather than only as psychological conflicts or chemical imbalances, as they were considered in the past. Current medications are not sufficient for most patients. A new and deep understanding of the pathophysiology of these disabling disorders is our best hope for a new generation of treatments that will help patients to recover.

引用

页码：700 / 705

页数：6

共 66 条

[1]

AMINOFF MJ, 2001, NEUROLOGY GEN MED

[2]

Bush G., 1990, PRESIDENTIAL PROCLAM

[3] The empirical status of cognitive-behavioral therapy: A review of meta-analyses [J].

Butler, AC ;

Chapman, JE ;

Forman, EM ;

Beck, AT .

CLINICAL PSYCHOLOGY REVIEW, 2006, 26 (01) :17-31

[4] Prediction of psychosis in youth at high clinical risk [J].

Cannon, Tyrone D. ;

Cadenhead, Kristin ;

Cornblatt, Barbara ;

Woods, Scott W. ;

Addington, Jean ;

Walker, Elaine ;

Seidman, Larry J. ;

Perkins, Diana ;

Tsuang, Ming ;

McGlashan, Thomas ;

Heinssen, Robert .

ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (01) :28-37

[5]

Cardno AG, 2000, AM J MED GENET, V97, P12, DOI 10.1002/(SICI)1096-8628(200021)97:1<12::AID-AJMG3>3.3.CO

[6]

2-L

[7] The DISC locus in psychiatric illness [J].

Chubb, J. E. ;

Bradshaw, N. J. ;

Soares, D. C. ;

Porteous, D. J. ;

Millar, J. K. .

MOLECULAR PSYCHIATRY, 2008, 13 (01) :36-64

[8] Fluoxetine versus other types of pharmacotherapy for depression [J].

Cipriani, A. ;

Brambilla, P. ;

Furukawa, T. A. ;

Geddes, J. ;

Gregis, M. ;

Hotopf, M. ;

Malvini, L. ;

Barbui, C. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2005, (04)

[9]

Colton Craig W, 2006, Prev Chronic Dis, V3, pA42

[10] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene [J].

Duerr, Richard H. ;

Taylor, Kent D. ;

Brant, Steven R. ;

Rioux, John D. ;

Silverberg, Mark S. ;

Daly, Mark J. ;

Steinhart, A. Hillary ;

Abraham, Clara ;

Regueiro, Miguel ;

Griffiths, Anne ;

Dassopoulos, Themistocles ;

Bitton, Alain ;

Yang, Huiying ;

Targan, Stephan ;

Datta, Lisa Wu ;

Kistner, Emily O. ;

Schumm, L. Philip ;

Lee, Annette T. ;

Gregersen, Peter K. ;

Barmada, M. Michael ;

Rotter, Jerome I. ;

Nicolae, Dan L. ;

Cho, Judy H. .

SCIENCE, 2006, 314 (5804) :1461-1463

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