A study of the mechanism of action of befol on Ca2+ metabolism in cardiomyocytes using a FURA-2 fluorescent probe

被引：7
作者：
Sergeev, PV
GalenkoYaroshevskii, PA
Khankoeva, AI
Dukhanin, AS
机构：
[1] RUSSIAN STATE MED UNIV,DEPT MOL PHARMACOL & RADIOBIOL,MOSCOW 117437,RUSSIA
[2] KUBAN MED ACAD,DEPT PHARMACOL,KRASNODAR,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1996年 / 121卷 / 03期
关键词：
calcium; befol; amiloride; strophanthin; caffeine; cardiomyocytes;
D O I：
10.1007/BF02446765
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The dynamics of the Ca-response of cardiomyocytes is studied and the efficiency of befol, verapamil, and amiodarone is compared using various experimental models of stimulation of [Ca2+](i). Befol (1-5 mu M) is shown to inhibit the caffeine- and strophanthin G-induced rise of [Ca2+](i). Unlike verapamil and amiodarone, befol exhibits no Ca-blocking activity in modeled K-depolarization. It is concluded that the cardiotropic effect of befol is mediated through its primary action on Na+/Ca2+ exchange in cardiomyocytes, while the cardioplegic effect of verapamil and amiodarone is due to their ability to block the slow Ca2+ inward current.
引用
收藏
页码：265 / 267
页数：3
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